{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:52Z","timestamp":1790618272731,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Branch atheromatous disease (BAD) carries a high risk of early neurological deterioration (END). We evaluated the efficacy of preemptive tirofiban administration within 72\u2009h compared with reactive rescue therapy following END.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective, single\u2010center study enrolled 221 patients with BAD\u2010associated stroke. Based on the timing of tirofiban administration, patients were assigned to a preemptive intervention group (\n n<\/jats:italic>\n \u2009=\u2009127) or a conventional intervention group (\n n<\/jats:italic>\n \u2009=\u200994). Preemptive intervention was defined as preemptive administration after clinical risk assessment, whereas conventional intervention was delayed until an increase of \u2265\u20092 points on the NIHSS score. Inverse probability of treatment weighting (IPTW) was applied to balance baseline covariates. Multivariable regression analysis was performed to identify independent predictors of an excellent 90\u2010day outcome, defined as a modified Rankin Scale (mRS) score \u2264\u20091.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After IPTW adjustment, the preemptive intervention group showed a significantly higher rate of excellent 90\u2010day outcomes (76.6% vs. 44.6%,\n p<\/jats:italic>\n \u2009<\u20090.001) and a shorter median hospital stay (10 vs. 11\u2009days,\n p<\/jats:italic>\n \u2009=\u20090.02) compared with the conventional group. No between\u2010group differences were observed in mortality or stroke recurrence (\n p<\/jats:italic>\n \u2009>\u20090.05). Early tirofiban use (adjusted OR\u2009=\u20094.411, 95%\n CI<\/jats:italic>\n : 2.349\u20138.283) and a lower baseline NIHSS score (adjusted OR\u2009=\u20090.832, 95%\n CI<\/jats:italic>\n : 0.707\u20130.980) independently predicted favorable outcomes. Subgroup analyses confirmed consistent benefits across most strata, with patients aged over 65\u2009years deriving greater neuroprotection (\n p<\/jats:italic>\n \u2009=\u20090.004 for age\u2010treatment interaction).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Preemptive administration of tirofiban within the initial 72\u2009h significantly improves 90\u2010day neurological outcomes and reduces hospital stay length in patients with BAD\u2010related stroke.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cns.71120","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:59:34Z","timestamp":1788447574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Preemptive vs. Conventional Tirofiban Administration on the Outcomes in Acute Branch Atheromatous Disease: A Propensity Score\u2010Weighted Cohort Study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8446-6866","authenticated-orcid":false,"given":"Chunying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7748-2493","authenticated-orcid":false,"given":"Dongsheng","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology Songyuan Jilin Oilfield Hospital Songyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864251357274"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1246"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-025-00807-w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.044"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1322-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.02.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.15441\/ceem.24.220"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70467"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.123201"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.04.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.65653"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2021-001166"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-025-02222-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.0868"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cns.70718"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.047688"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032966"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.632307"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241273685"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2023-002998"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151678"},{"issue":"6","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70508","article-title":"Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta\u2010Analysis","volume":"15","author":"Kamran A. 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