{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:58Z","timestamp":1790618278474,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3341300"],"award-info":[{"award-number":["2023YFC3341300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20241881"],"award-info":[{"award-number":["BK20241881"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571269"],"award-info":[{"award-number":["32571269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371556"],"award-info":[{"award-number":["82371556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emotional disorders (EDs), including anxiety disorders, major depression (MDD), and post\u2010traumatic stress disorder (PTSD), show overlapping symptoms and neurobiological heterogeneity, limiting current diagnostic frameworks. Transdiagnostic biomarkers are critical for precision psychiatry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional connectivity (FC) from 261 ED patients and 201 healthy controls (HCs) was decomposed via nonnegative matrix factorization (NMF). Differential FC features defined latent disease factors, classifying patients into subtypes with distinct network\/structural profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis identified five representative functional networks (RFNs) underlying the heterogeneity of emotional disorders. RFN1 reflected connectivity between sensorimotor and dorsal attention networks, while RFN2 was defined by theory\u2010of\u2010mind\u2010related connectivity. RFN3, characterized by thalamocortical connections, was specifically linked to somatic sensation processing. RFN4 involved connectivity within the default mode network, and RFN5 captured multi\u2010network\u2010subcortical integration. These RFNs delineated five subtypes with distinct clinical profiles: ST1 (mixed anxiety\/depression) exhibited RFN1\u2010driven somatic vigilance and comorbid depressive symptoms; ST2 (mild symptoms) demonstrated resilience associated with RFN2; ST3 (somatic anxiety\u2010dominant) showed RFN3\u2010related elevations in somatic anxiety and panic symptoms; ST4 (anxiety\u2010centric) was marked by RFN4\u2010associated self\u2010referential anxiety; and ST5 represented a depression\u2010pure subgroup mapped to RFN5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study proposes a neurobiologically informed stratification for EDs, revealing transdiagnostic subtypes with distinct network signatures and clinical implications. The findings bridge symptom heterogeneity to circuit\u2010level dysfunction, offering potential biomarkers for personalized interventions and advocating for transdiagnostic approaches in psychiatric research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71122","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:08:20Z","timestamp":1788246500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoding Transdiagnostic Subtypes in Emotional Disorders"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-408X","authenticated-orcid":false,"given":"Yun","family":"Wu","sequence":"first","affiliation":[{"name":"School of Psychology Nanjing Normal University  Nanjing China"},{"name":"Taizhou Fifth People's Hospital, Jiangsu  Taizhou Jiangsu China"},{"name":"Adolescent Education and Intelligence Support Lab of Nanjing Normal University, Laboratory of Philosophy and Social Sciences at Universities in Jiangsu Province  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-9679","authenticated-orcid":false,"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8083-2039","authenticated-orcid":false,"given":"Changjun","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology The Affiliated Brain Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Taizhou Fifth People's Hospital, Jiangsu  Taizhou Jiangsu 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