{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:51Z","timestamp":1790618271380,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203170"],"award-info":[{"award-number":["82203170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["JQ23040"],"award-info":[{"award-number":["JQ23040"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The efficacy of awake craniotomy (AC) with intraoperative mapping for glioblastoma (GBM) in eloquent regions remains debated. This study aims to evaluate functional and survival outcomes of GBM patients undergoing AC stratified by tumor locations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A combined retrospective (2015\u20132023,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009114: 43\u2009AC vs. 71 standard craniotomy) and prospective cohort (2023\u20132025,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928: 13\u2009AC vs. 15 standard craniotomy) of GBM patients with motor\/language\u2010eloquent tumors was analyzed. Tumors were classified into motor subtypes (I: precentral gyrus; II: premotor\/supplementary motor; III: internal capsule posterior limb; IV: other) and language subtypes (I: Broca's\/precentral; II: postcentral\/supramarginal gyrus; III: Wernicke's; IV: insular; V: other). Outcomes included extent of resection (EOR), postoperative motor\/language recovery, overall survival (OS), and progression\u2010free survival (PFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The retrospective cohort demonstrated that AC has advantages in functional preservation across various motor\/language subtypes. However, AC was associated with significantly deteriorated survival outcomes specifically in precentral gyrus GBMs. A prospective cohort study, enrolling only precentral gyrus GBMs for validation, yielded results consistent with the retrospective findings: worsened OS and PFS (OS: HR\u2009=\u20093.223,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0450; PFS: HR\u2009=\u20092.374,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0476); reduced EOR (AC:\u00a074.3%\u2009\u00b1\u20095.3%; standard craniotomy: 86.9%\u2009\u00b1\u200912.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0470); and better motor recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Functional preservation and survival outcomes of AC in GBM exhibited subtype\u2010specific correlations with tumor locations. AC with intraoperative mapping effectively preserves neurological function in GBM patients. However, for tumors involving the precentral gyrus, the AC approach carries greater risks than benefits and should be considered with caution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Strategic Intervention on Preserving Motor Function During Awake Craniotomy: NCT05143788. Strategic Intervention on Preserving Language Function During Awake Craniotomy: NCT05143775<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71126","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:20:34Z","timestamp":1788409234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Awake Craniotomy for Eloquent Region Glioblastoma Classified by Tumor Location\u2014A Retrospective and Prospective Cohort Study"],"prefix":"10.1002","volume":"32","author":[{"given":"Yuzhe","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing 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