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However, clinical optimization is hindered by a lack of interpretable prognostic biomarkers, and the neural mechanisms associated with recovery after SCS remain largely elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nineteen DoC patients undergoing 70\u2009Hz SCS were enrolled and categorized into effective (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) and ineffective (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) groups based on longitudinal clinical improvements. Resting\u2010state electroencephalography (EEG) was recorded across baseline, intra\u2010stimulation, and poststimulation phases. To investigate neural dynamics, theta\u2010band dynamic functional connectivity (dFC) was analyzed using the weighted phase lag index (wPLI) combined with a sliding window approach. Global and local dFC metrics, alongside region\u2010specific connectivity strengths, were quantified to characterize the global\u2013local collaborative mechanisms induced by SCS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the ineffective group, the effective group demonstrated enhanced global integration and decoupled regional segregation under SCS, evidenced by synchronized reduction in global average path length and suppression in local clustering (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>TPL<\/jats:sub>\n                      \u2009=\u20090.0090;\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>TLE<\/jats:sub>\n                      \u2009=\u20090.0090;\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>TCC<\/jats:sub>\n                      \u2009=\u20090.0378). Regionally, increased functional connectivity was primarily observed in the right temporal cortex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0054), whereas decreased connectivity was identified in the left occipital region (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0218). Furthermore, dynamic EEG features were significantly correlated with 3\u2010month CRS\u2010R improvement scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This dynamic global and local enhancement in the theta\u2010band dFC serves as an interpretable neural marker for predicting SCS efficacy. These findings offer novel insights into the system\u2010level collaborative mechanisms essential for consciousness restoration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2200061278<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71128","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:23:41Z","timestamp":1788150221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Global and Local Enhancement of Theta\u2010Band Functional Networks as Neural Markers of Spinal Cord Stimulation Efficacy in Disorders of 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