{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:51Z","timestamp":1793345571645,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572162"],"award-info":[{"award-number":["82572162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001790"],"award-info":[{"award-number":["82001790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502308"],"award-info":[{"award-number":["82502308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fluoxetine is an established pharmacological intervention for bulimia nervosa (BN); however, the macroscopic functional network remodeling underlying its efficacy in suppressing eating impulsivity remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010eight patients with BN and 58 healthy controls assessed at both baseline and follow\u2010up underwent resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI). Network\u2010Based Statistic (NBS) analysis with edgewise paired comparisons was used to identify whole\u2010brain connectivity changes in patients with BN. The resulting BN\u2010derived component was subsequently examined in both groups using a Group \u00d7 Time analysis. Exploratory brain\u2010behavior associations within BN were examined using Spearman and partial Spearman correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During follow\u2010up, patients with BN showed significant improvements in depressive symptoms and externally driven eating behavior. Within\u2010group NBS analysis identified a 23\u2010edge component showing reduced functional connectivity in BN at follow\u2010up, with network\u2010level family\u2010wise error correction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). This component primarily involved dorsal attention, ventral attention\/salience, and somatomotor networks. Whole\u2010brain NBS analysis in healthy controls did not identify a significant longitudinal component. When mean connectivity of the BN\u2010derived component was extracted in both groups, connectivity decreased more strongly in BN than in healthy controls (Group \u00d7 Time\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.053,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The follow\u2010up period in patients with BN was accompanied by clinical improvement and reduced functional connectivity among attention\u2010, salience\u2010, and sensorimotor\u2010related systems. These findings provide preliminary evidence of treatment\u2010period\u2010associated functional network reconfiguration in BN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ChiCTR2200066885<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71129","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:19:35Z","timestamp":1788286775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurobehavioral Association Between Macroscopic Network Decoupling and Reduced Eating Impulsivity: A Longitudinal\n                    <scp>fMRI<\/scp>\n                    Study in Bulimia Nervosa"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9510-4707","authenticated-orcid":false,"given":"Yulong","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-7385","authenticated-orcid":false,"given":"Weihua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Radiology Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3970-3008","authenticated-orcid":false,"given":"Fengxia","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Wu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-7824","authenticated-orcid":false,"given":"Jiani","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-6469","authenticated-orcid":false,"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Precision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Tang","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-0036","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM\u20105","author":"Guha M.","year":"2014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.06.041"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22929"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113354"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22411"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000381"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2023.2179663"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820020059008"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30015-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0406-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.03.007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102671"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25602"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01152-w"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14166-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23560"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-023-00538-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14030200"},{"key":"e_1_2_12_20_1","volume-title":"The MINI International Neuropsychiatric Interview (Version 7.0. 2) for DSM\u20105","author":"Sheehan D.","year":"2016"},{"key":"e_1_2_12_21_1","volume-title":"Statistical Manual of Mental Disorders,(DSM\u20105) Washington","author":"Diagnostic A.","year":"2013"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.23180001"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S25574"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820020059008"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agaa119"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25949"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-018-1041-8"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.96"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24028"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.09.029"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.899605"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2023.08.016"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1133367"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-022-00534-9"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-022-01390-x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/20551029241262665"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1149864"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-023-00833-9"}],"container-title":["CNS Neuroscience &amp; 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