{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:58:24Z","timestamp":1790618304832,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271965"],"award-info":[{"award-number":["82271965"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330059"],"award-info":[{"award-number":["82330059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cerebral small vessel disease (CSVD) is associated with altered spontaneous brain activity on resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI). However, MRI studies usually overlook the potential effects of postural change. This study characterized posture\u2010related alterations in spontaneous brain activity in CSVD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty\u2010one CSVD patients and 30 normal controls (NCs) underwent multi\u2010position MRI, including upright and supine rs\u2010fMRI. Amplitude of low\u2010frequency fluctuations (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were calculated, and supine\u2010upright differences (\u0394) were derived. Mixed\u2010design ANOVA assessed group, position, and interaction effects. Within\u2010group and between\u2010group differences were examined, followed by cognition\u2010related analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main effect of posture on ReHo was observed in frontal, temporal, and parietal cortices and deep gray nuclei. In the upright position, CSVD patients had higher ReHo in the right anterior cingulate gyrus than NCs, which was associated with worse global cognitive function and a higher composite CSVD score. CSVD patients also exhibited widespread posture\u2010related ReHo alterations. Regression analyses demonstrated that \u0394ReHo in the left hippocampus was positively associated with memory function, whereas \u0394ReHo in the right putamen and left calcarine cortex was associated with the composite CSVD score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upright imaging and upright\u2010supine comparison may help unmask latent posture\u2010related ReHo abnormalities in patients with CSVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71140","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:30:23Z","timestamp":1788849023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posture\u2010Related Regional Homogeneity Abnormalities in\u00a0Cerebral Small Vessel Disease: A Multi\u2010Position\n                    <scp>MRI<\/scp>\n   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