{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:58Z","timestamp":1790618278754,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010stroke epilepsy (PSE) is a common and serious complication of stroke, yet simple and efficient risk assessment tools remain lacking in clinical practice. This study aimed to investigate the association between multiple core inflammation\u2010derived indices and PSE, and to explore their potential reference value in risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective case\u2013control study, we extracted data from hospitalized stroke patients at Hefei Second People's Hospital between January 2018 and December 2025 from the electronic medical record system. A 1:1 propensity score matching method was used to balance confounding factors including sex, age, and underlying diseases. Ultimately, 317 PSE patients (case group) and 317 stroke patients without PSE (control group) were included. Routine hematological parameters collected within 24\u2009h of admission were used to calculate six inflammatory indices: the systemic immune\u2010inflammation index (SIRI), neutrophil\u2010to\u2010lymphocyte ratio (NLR), derived neutrophil\u2010to\u2010lymphocyte ratio (DNLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), neutrophil\u2010to\u2010platelet ratio (NPR), and neutrophil\u2013monocyte\u2010to\u2010lymphocyte ratio (NMLR). Multivariable logistic regression models were employed to analyze the association between inflammatory indices and PSE risk, and nonlinear relationships and threshold effects were also explored. The discriminative ability and incremental value of each inflammatory index were assessed using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Subgroup analyses were conducted to verify the stability of the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study showed that for each one\u2010standard\u2010deviation increase in SIRI, the risk of PSE increased by 172% (OR\u2009=\u20092.72, FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Quartile\u2010stratified analysis revealed a clear dose\u2013response relationship (trend\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similarly, the strength of association for SIRI was superior to that of other inflammation\u2010derived indices. Compared with the other inflammatory indices, SIRI demonstrated relatively better discriminative ability in ROC analysis (AUC\u2009=\u20090.693, 95% CI: 0.654\u20130.732), NRI, and DCA. Restricted cubic spline regression and\n                      <jats:italic>E<\/jats:italic>\n                      \u2010value analysis further supported the robustness of this association, and subgroup analyses indicated consistency across different subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic immune\u2010inflammation index showed a relatively strong association with PSE risk and moderate discriminative ability in the stroke population, and may serve as an auxiliary reference indicator for early risk stratification of post\u2010stroke epilepsy. However, its clinical utility requires further validation in prospective cohort studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71143","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:10:32Z","timestamp":1788873032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Multiple Inflammation\u2010Derived Indices and the Risk of Post\u2010Stroke Epilepsy"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6772-0141","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate School of Wan Nan Medical College  Wuhu Anhui China"},{"name":"Department of Neurology The Second People's Hospital of Hefei  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YeQin","family":"Gao","sequence":"additional","affiliation":[{"name":"Anhui Medical University  Hefei Anhui China"},{"name":"The Fifth Clinical School of Medicine, Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9648-9987","authenticated-orcid":false,"given":"Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second People's Hospital of Hefei  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(24)00369\u20107"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000477"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231213231"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7692215"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14294"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint18010001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2008.01989.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fstro.2023.1119120"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1640796"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109177"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109660"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S257870"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16648"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.781174"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(17)30404\u20100"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.0611"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26497"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010023\u201003510\u20101"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209450"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12070"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010025\u201006609\u20104"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102903"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2023.11.006"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109752"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1286351"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1537566"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2025.108996"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00425"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15101083"}],"container-title":["CNS Neuroscience &amp; 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