{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:12Z","timestamp":1790618232234,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Synaptic loss is a neuropathological feature of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Cerebello\u2010cerebral synaptic function was evaluated in female first\u2010episode major depressive disorder (MDD) patients using [\n                      <jats:sup>18<\/jats:sup>\n                      F]UCB\u2010H positron emission tomography (PET).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      PET was performed on female first\u2010episode MDD patients (FMD group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), healthy controls (HC group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), and chronic restraint stress (CRS) mice (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). Standardized uptake value ratios (SUVR), voxel\u2010wise tracer uptake analysis, functional connectivity (FC), and network analysis were performed at the cerebello\u2010cerebral level. Associations with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) scores were assessed by Pearson correlation and logistic regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the FMD group, SUVR in the left cerebellum 7b was significantly reduced and negatively correlated with HAMD (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.57) and HAMA (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.55) scores. The cluster centered on the left cerebellar lobule VIII showed reduced tracer uptake and was negatively correlated with HAMD scores. FC was significantly reduced in the right frontal lobe but enhanced in the midbrain and occipital regions. The network was characterized by bilateral frontal lobe concentration in the FMD group, while the cerebellar network was more uniform. Cerebello\u2010cerebral uncoupling between the left cerebellum and the right frontal lobe was observed, manifested as reduced SUVR correlation and weakened FC. CRS mice also showed reduced brain [\n                      <jats:sup>18<\/jats:sup>\n                      F]UCB\u2010H uptake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Left cerebellar\u2010right frontal uncoupling may serve as a potential neural correlate of first\u2010episode MDD in females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71144","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:30:48Z","timestamp":1788589848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Cerebellar\u2010Right Frontal Uncoupling in Female First\u2010Episode Major Depressive Disorder: Synaptic Evidence From [\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>UCB<\/scp>\n                    \u2010H\n                    <scp>PET<\/scp>"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2596-4918","authenticated-orcid":false,"given":"Juehan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4352-595X","authenticated-orcid":false,"given":"Yajun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pain Management and Rehabilitation Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6899-6317","authenticated-orcid":false,"given":"Pengfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-9942","authenticated-orcid":false,"given":"Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  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