{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:48Z","timestamp":1793345568566,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230155"],"award-info":[{"award-number":["BK20230155"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Artesunate (ART) has shown neuroprotective potential, but its effects on glymphatic\u2010related fluid transport in Parkinson's disease (PD) remain unclear. This pilot study aimed to explore whether ART affects glymphatic\u2010related fluid transport in a PD mouse model and to assess the feasibility of evaluating these changes in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      C57BL\/6 WT and A53T mice (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 each) were divided into four groups (WT, WT\u2009+\u2009ART, A53T, and A53T\u2009+\u2009ART) and treated with ART or DMSO for 7\u2009days. Glymphatic\u2010related fluid transport was assessed by dynamic MRI after intraventricular Gd\u2010DTPA injection. Immunofluorescence evaluated \u03b1\u2010syn, AQP4, and AQP4\u2010GFAP colocalization, while transmission electron microscopy (TEM) assessed astrocytic end\u2010feet integrity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ART was associated with regionally heterogeneous changes in tracer\u2010related MRI signal dynamics in both WT and A53T mice. In PD mice, ART was associated with partial restoration of AQP4 polarization in selected brain regions and improved perivascular astrocytic end\u2010feet morphology, accompanied by reduced \u03b1\u2010syn immunofluorescence signal in the substantia nigra.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ART was associated with regionally heterogeneous changes in glymphatic\u2010related fluid transport dynamics and AQP4 polarization in this pilot PD mouse study. These preliminary findings support further investigation of ART as a potential modulator of brain fluid transport\u2010related pathways in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71145","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:19:45Z","timestamp":1789564785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Pilot Study Evaluating the Effect of Artesunate on Glymphatic\u2010Related Fluid Transport in Parkinson's Disease Mouse Models In\u00a0Vivo and Ex\u00a0Vivo"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6887-4559","authenticated-orcid":false,"given":"Wan\u2010ting","family":"Han","sequence":"first","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"},{"name":"Department of Radiology, Shanghai Pudong Hospital Fudan University Affiliated Pudong Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010hui","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-6684","authenticated-orcid":false,"given":"Guang\u2010hui","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-7578","authenticated-orcid":false,"given":"Xin\u2010ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-4945","authenticated-orcid":false,"given":"Tong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00764"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab428"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104987"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab311"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.03.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03212-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0637-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12369"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.972-977.2000"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084165"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.12.001"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1489050"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211053549"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13848"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115972"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14063"},{"key":"e_1_2_12_19_1","article-title":"Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System","volume":"75","author":"DeVos S. 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