{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:51:58Z","timestamp":1791211918232,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021ZD0201801"],"award-info":[{"award-number":["2021ZD0201801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371306"],"award-info":[{"award-number":["82371306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Epilepsy is a common neurological disorder, often presenting with psychiatric comorbidities and cognitive impairment. Neuroimaging studies have suggested associations between epilepsy and subcortical volumetric abnormalities. The genetic basis between epilepsy and subcortical volume abnormalities is, however, poorly understood, particularly if they share a common genetic architecture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To investigate polygenic overlap, we employed the bivariate causal mixture model (MiXeR) to analyze genome\u2010wide association data from various epilepsy subtypes (genetic generalized epilepsy [GGE]:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949,388, all epilepsy [EP]:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969,995, focal epilepsy:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200957,375) and 16 subcortical volumetric phenotypes (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933,224). We identified shared genomic loci through conditional and conjunctional false discovery rate analyses (cond\/conjFDR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MiXeR results suggest substantial shared genetic variants between subcortical volume and common epilepsies. ConjFDR analysis identified 33 distinct shared loci between GGE and subcortical volumetric phenotypes. The shared loci were mapped to 322 protein\u2010coding genes. Among these, 49 genes showed significant expression\u2010trait associations with both GGE and subcortical volume phenotypes, and 12 of the 322 genes were also associated with cognitive, mental health, and personality\u2010related traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We dissected the shared genetic architecture between common epilepsies and subcortical volumes. Expression\u2010trait association analyses further identified candidate genes associated with cognitive, mental health, and personality\u2010related phenotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71156","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:54:52Z","timestamp":1791208492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared Genetic Architecture Between Common Epilepsies and Subcortical Brain Volumes Is Associated With Cognition and Mental Health"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9257-1058","authenticated-orcid":false,"given":"Zesheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-044X","authenticated-orcid":false,"given":"Jianwei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8261-5808","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-8974","authenticated-orcid":false,"given":"Yumin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Oncology and Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-1026","authenticated-orcid":false,"given":"Yongzhi","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-4222","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9661","authenticated-orcid":false,"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London UK"},{"name":"Chalfont Centre for Epilepsy, Chalfont St Peter  Buckinghamshire UK"},{"name":"Neurology Department West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-5252","authenticated-orcid":false,"given":"Guoguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32596\u20100"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18338"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)00225\u20102"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12832"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.20220116"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad038"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00300\u20108"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102016\u2010313297"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.57.9.1636"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14101"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf097"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.08.020"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2005.00259.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz215"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2011.03045.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12428"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2012.03422.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13125"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061880"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51938"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx341"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14565"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70069"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.07.025"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010023\u201001485\u2010w"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010120219\u2010074937"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2024.2436866"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039539\u20106"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007524\u2010z"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105675"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001951\u2010z"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010310\u20100"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003455"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562\u2010020\u201001031\u20102"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.4188"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000826\u20104"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008612"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0688"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052121\u2010y"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052583\u20100"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001751\u2010z"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023175\u2010z"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100511\u2010y"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2024.09.016"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70171\u20101"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds373"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114794"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008757\u2010x"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562\u2010020\u201000936\u20102"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002352\u20101"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.197"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.1119"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562\u2010024\u201001951\u20103"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005473\u20108"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2024.06.001"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2025.06.010"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000651\u20108"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320504"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65636"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.03.008"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003642"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00443"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30204"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001085"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4563"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.039"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(24)00302\u20105"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.71156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:54:53Z","timestamp":1791208493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.71156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cns.71156"],"URL":"https:\/\/doi.org\/10.1002\/cns.71156","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71156"}}