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This exploratory sham\u2010controlled study evaluated a 50\u2010session a\u2010iTBS protocol for AUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010one male AUD inpatients were randomized to receive traditional iTBS (once daily, 600 pulse\/session), a\u2010iTBS (5\u00a0sessions\/day, 3000 pulses\/day), or sham iTBS. Treatments were administered on 10 weekdays (Monday to Friday over 2\u2009weeks) and targeted the dorsolateral prefrontal cortex. The primary outcome was the change in craving. The alcohol relapse behavior, emotional symptoms, and sleep quality were evaluated pre\u2010\/post\u2010intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Group showed no significant main effect on craving percentage change. The a\u2010iTBS group showed a higher response rate and earlier response onset than the s\u2010iTBS group, whereas no significant differences existed between a\u2010iTBS and iTBS, or iTBS and s\u2010iTBS. No intergroup differences were detected for mood and sleep indicators. At the 6\u2010month follow\u2010up, participants receiving a\u2010iTBS achieved longer abstinence duration than those given s\u2010iTBS. Exploratory logistic regression indicated that baseline GAD\u20107 scores and treatment group were associated with treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the primary craving outcome did not differ significantly among groups, a\u2010iTBS showed preliminary signals of earlier response and longer time to first relapse than sham stimulation. These exploratory findings require confirmation in larger trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71166","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:04:28Z","timestamp":1789563868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accelerated Intermittent Theta\u2010Burst Stimulation for the Treatment of Alcohol Use Disorder: A Randomized Sham\u2010Controlled Study With Six\u2010Month Follow\u2010Up"],"prefix":"10.1002","volume":"32","author":[{"given":"Yunsheng","family":"Hou","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University  Xinxiang Henan China"},{"name":"Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder The Second Affiliated Hospital of Henan Medical University  Xinxiang Henan 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