{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:38:23Z","timestamp":1793270303459,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A2059"],"award-info":[{"award-number":["U25A2059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011897"],"award-info":[{"award-number":["2023A1515011897"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515140070"],"award-info":[{"award-number":["2023A1515140070"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515011146"],"award-info":[{"award-number":["2025A1515011146"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the associations of reproductive factors (RFs) and postmenopausal sex hormone (PSH) with cognitive impairment (CI) in postmenopausal women with PD (PWPD), and to develop a predictive nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010five PWPD were divided into CI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972; Montreal Cognitive Assessment [MoCA]\u2009&lt;\u200926) and normal cognition (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923; MoCA\u2009\u2265\u200926) groups. RFs and serum PSH levels were collected. Risk factors were screened by logistic regression and confirmed via sensitivity and subgroup analyses. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Shorter reproductive lifespan (RLS) and lower education independently predicted CI in PWPD. Compared with RLS\u2009\u2265\u200939\u2009years, RLS\u2009\u2264\u200932\u2009years (adjusted OR\u2009=\u200912.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and 33\u201338\u2009years (adjusted OR\u2009=\u20098.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) were associated with significantly higher CI risks. The RLS\u2010CI association remained stable across sensitivity analyses and was more prominent in milder\u2010stage patients. No intergroup PSH differences were observed. A nomogram integrating RLS, education, age, disease duration, and Hoehn and Yahr stage (H&amp;Y stage) demonstrated satisfactory discrimination (AUC\u2009=\u20090.903), calibration, and net benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Shorter RLS independently predicts CI in PWPD, particularly in milder\u2010stage patients, while PSH shows no association. This nomogram may serve as a practical screening tool for CI in PWPD, pending external validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71182","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:30:27Z","timestamp":1791459027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Reproductive Factors and Postmenopausal Sex Hormones With Cognitive Impairment in Postmenopausal Women With Parkinson's Disease"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-2680","authenticated-orcid":false,"given":"Wen\u2010Zheng","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Guangzhou Medical University  Guangzhou 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