{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:57:55Z","timestamp":1790866675283,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32671478"],"award-info":[{"award-number":["32671478"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170104"],"award-info":[{"award-number":["82170104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2025206880"],"award-info":[{"award-number":["H2025206880"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The dorsomedial hypothalamus (DMH) integrates metabolism and autonomic homeostasis, but whether subnuclear functional topography exists remains unclear. This study compared whole\u2010brain input\u2013output connectomes of leptin receptor (LepRb) neurons in dorsal DMH (DMD) versus DMH to test for connection\u2010biased segregation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rabies monosynaptic retrograde tracing and Cre\u2010dependent AAV anterograde tracing in LepRb\u2010Cre mice mapped and quantified input\u2013output projections of DMD\n                      <jats:sup>LepRb<\/jats:sup>\n                      and DMH\n                      <jats:sup>LepRb<\/jats:sup>\n                      neurons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both DMD\n                      <jats:sup>LepRb<\/jats:sup>\n                      and DMH\n                      <jats:sup>LepRb<\/jats:sup>\n                      neurons received inputs from 58 upstream nuclei and projected to 43 downstream targets across the telencephalon, diencephalon, midbrain, pons, and medulla, forming extensive overlapping networks with similar global architectures. Nevertheless, they showed significant connection weight biases: DMD\n                      <jats:sup>LepRb<\/jats:sup>\n                      preferentially integrated arousal, defensive, and emotional signals and projected to stress\/defense\u2010related nuclei, whereas DMH\n                      <jats:sup>LepRb<\/jats:sup>\n                      preferentially integrated viscerosensory and reward\u2010aversion signals and projected to metabolic\/circadian nuclei.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      DMD\n                      <jats:sup>LepRb<\/jats:sup>\n                      and DMH\n                      <jats:sup>LepRb<\/jats:sup>\n                      neurons share highly homologous whole\u2010brain input\u2013output architecture but exhibit local connection\u2010weight biases, revealing conserved architecture with local specialization and providing a circuit basis for functional heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71185","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:26:13Z","timestamp":1790864773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain\u2010Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus"],"prefix":"10.1002","volume":"32","author":[{"given":"Yaxin","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5302-3252","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7174-6534","authenticated-orcid":false,"given":"Yongqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8340-0305","authenticated-orcid":false,"given":"Mengchu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"},{"name":"Department of Laboratory Diagnostics Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-1572","authenticated-orcid":false,"given":"Fang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University  Shijiazhuang Hebei China"},{"name":"Hebei Key Laboratory of Brain Science and Brain\u2010Inspired Intelligence, Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12986-021-00582-z","article-title":"The Deletion of Glucagon\u2010Like Peptide\u20101 Receptors Expressing Neurons in the Dorsomedial Hypothalamic Nucleus Disrupts the Diurnal Feeding Pattern and Induces Hyperphagia and Obesity","volume":"18","author":"Maejima Y.","year":"2021","journal-title":"Nutrition & Metabolism"},{"issue":"3","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0091-3057(01)00689-X","article-title":"The Dorsomedial Hypothalamus and the Response to Stress: Part Renaissance, Part Revolution","volume":"71","author":"DiMicco J. 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