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The precise identification of its neuroimaging markers is of core value for early diagnosis, elucidation of its pathological mechanism, and individualized treatment. Recent advances in magnetic resonance imaging (MRI) and artificial intelligence (AI) have enabled automated, high\u2010throughput characterization of CSVD\u2010related brain lesions. However, the translation of these technical advances into clinical tools for depression\u2010specific prediction and classification remains at an early stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>This manuscript aims to summarize the application of traditional visual scoring systems in assessing the burden of CSVD and its association with depressive symptoms. Review the current status of imaging and AI research on CSVD\u2010related depression. To provide a direction for the development of more precise and efficient imaging diagnostic tools for the future, and ultimately promote the practical application and utilization of precision medicine in the field of CSVD\u2010related depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71188","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:44:36Z","timestamp":1790829876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Resonance Imaging in Cerebral Small Vessel Disease\u2010Related Depression: From Visual Scoring to Artificial Intelligence"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6659-2518","authenticated-orcid":false,"given":"Chaofang","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-6233","authenticated-orcid":false,"given":"Jiaxu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"},{"name":"Guangzhou Key Laboratory of Formula\u2010Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"},{"name":"National Center for Neurological Disorders  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106368"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14030269"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13091323"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.19538\/j.nk2021070106"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.13479\/j.cnki.jip.2025.04.025"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2025.100396"},{"issue":"1","key":"e_1_2_16_8_1","first-page":"35","article-title":"Cerebral Small Vessel Disease and Post\u2010Stroke Depression","volume":"6","author":"Sun X. 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