{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:03Z","timestamp":1792794723251,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503904"],"award-info":[{"award-number":["2022YFC2503904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by REM sleep without atonia (RSWA) and dream\u2010enactment behaviors and is recognized as a prodromal manifestation of \u03b1\u2010synucleinopathies. Isolated RSWA (iRSWA) has been proposed as a potential early stage within the RBD spectrum, although its clinical and physiological significance remains incompletely understood. This study aimed to investigate alterations in sleep architecture, phasic muscle activity, and dynamic cerebral autoregulation (dCA) across the spectrum from iRSWA to isolated RBD (iRBD) and Parkinson's disease with RBD (PD\u2009+\u2009RBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case\u2013control study involving patients with iRSWA, iRBD, and PD\u2009+\u2009RBD, as well as age\u2010 and sex\u2010matched healthy controls, based on video\u2010polysomnography and magnetic resonance imaging. Scales for Outcomes in Parkinson's Disease\u2010Autonomic Dysfunction (SCOPA\u2010AUT) were used to evaluate the autonomic function. Transcranial Doppler and finger plethysmography were used to assess dCA by analyzing the phase difference using transfer function analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 patients with iRSWA, 30 with iRBD, 28 with PD\u2009+\u2009RBD, and 30 healthy controls were included. REM sleep percentage was significantly lower in the iRBD and PD\u2009+\u2009RBD groups than in controls. Phasic RSWA, but not tonic RSWA, differed significantly among the three patient groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Phase difference was significantly lower in all three patient groups than in controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and was significantly associated with REM sleep amount and phasic RSWA (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that dCA is impaired in patients with iRSWA, iRBD, and PD\u2009+\u2009RBD. Reduced phase difference was associated with lower REM sleep amount and greater phasic RSWA, suggesting disrupted coupling among REM sleep regulation, autonomic function, and cerebrovascular control. dCA dysfunction may represent an early pathophysiological feature in RBD\u2010related neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      Identifier: NCT02752139\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71190","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:06:16Z","timestamp":1792605976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired Dynamic Cerebral Autoregulation Across the\n                    <scp>REM<\/scp>\n                    Sleep Behavior Disorder Spectrum: Evidence From Isolated\n                    <scp>REM<\/scp>\n                    Sleep Without Atonia to Parkinson's Disease With\n                    <scp>RBD<\/scp>"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4428-1059","authenticated-orcid":false,"given":"Yanan","family":"Zhang","sequence":"first","affiliation":[{"name":"Sleep Center, Department of Neurology The First Hospital of Jilin University  Changchun China"},{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Piao","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Neurology The First Hospital of Jilin University  Changchun China"},{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Neurology The First Hospital of Jilin University  Changchun China"},{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Neurology The First Hospital of Jilin University  Changchun China"},{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Wang","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Neurology The First Hospital of Jilin University  Changchun China"},{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenni","family":"Guo","sequence":"additional","affiliation":[{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-7832","authenticated-orcid":false,"given":"Zan","family":"Wang","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Neurology The First Hospital of Jilin University  Changchun China"},{"name":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24957"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010016\u20109831\u20104"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.157"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13156"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)00057\u20100"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.09.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.010"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(13)70056\u20105"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp244"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207883"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00954.2005"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14123"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.12.1729"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23721"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00051"},{"issue":"6","key":"e_1_2_13_19_1","first-page":"916","article-title":"The International Classification of Sleep Disorders, Third Edition. American Academy of Sleep Medicine. Includes Bibliographies and Index","volume":"73","author":"Ito E.","year":"2015","journal-title":"Nihon Rinsho"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102869.2008.00631.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.03.013"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1886"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.08.033"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.12.020"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20153"},{"key":"e_1_2_13_27_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Berry R. B.","year":"2020"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.13"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23347"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.07.015"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5184"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0350467"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000242879.39415.49"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2010.03283.x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12068"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213470"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2019.05.005"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010017\u20100460\u20104"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1353\u20108020(03)00069\u20105"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353\u20108020(01)00014\u20101"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.12.017"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.03.007"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20104580(02)00065\u20109"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04767"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91349.2008"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109558"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0688\u201020.2020"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(92)90508\u20107"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101305"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13640"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6312"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.8.1019"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361\u20109230(95)00030\u2010I"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20\u201017\u201006640.2000"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm056"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010011\u20101054\u2010y"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20112"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ca0166"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.106805"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab257"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.71190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:06:18Z","timestamp":1792605978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.71190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cns.71190"],"URL":"https:\/\/doi.org\/10.1002\/cns.71190","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71190"}}