{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:57:32Z","timestamp":1791017852482,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871016"],"award-info":[{"award-number":["81871016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["PL2024H103"],"award-info":[{"award-number":["PL2024H103"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine whether the apoptin\u2010derived peptide (also named B9) reduces evoked seizure susceptibility and kainic acid (KA)\u2010associated cognitive and molecular abnormalities, and to define whether these effects involve the heat shock protein family A member 1A (HSPA1A)\u2013adaptor protein complex 2 subunit beta 1 (AP2B1) pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The therapeutic efficacy of B9 was examined in a pentylenetetrazol (PTZ)\u2010induced acute seizure model and a KA\u2010induced temporal lobe epilepsy (TLE) model. Electroencephalographic (EEG) recordings were performed to evaluate epileptiform activity. The Barnes maze test was used to assess cognitive function in epileptic mice. Western blotting, co\u2010immunoprecipitation (Co\u2010IP), immunofluorescence (IF), and calcium imaging were used to investigate the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      B9 reduced seizure susceptibility, attenuated epileptiform activity, and improved spatial learning and memory. HSPA1A was markedly upregulated in TLE\u2010related datasets and experimental models. B9 suppressed the expression of HSPA1A and disrupted its interaction with AP2B1, which restored O\u2010linked \u03b2\u2010N\u2010acetylglucosamine (O\u2010GlcNAc) modification and protein stability of AP2B1, preserved GluA2 expression, and limited neuronal Ca\n                      <jats:sup>2+<\/jats:sup>\n                      overload. Knockdown of AP2B1 abolished the effects of B9 on evoked seizure susceptibility, cognitive performance, GluA2 abundance, and neuronal Ca\n                      <jats:sup>2+<\/jats:sup>\n                      overload, whereas AP2B1 overexpression reproduced the reductions in PTZ\u2010evoked seizure susceptibility and EEG activity observed with B9.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>B9 reduces PTZ\u2010evoked seizure susceptibility and ameliorates KA\u2010associated cognitive and molecular abnormalities through modulation of the HSPA1A\u2013AP2B1 axis. These findings support B9 as a potential therapeutic strategy for TLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71193","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:47:52Z","timestamp":1791017272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apoptin\u2010Derived Peptide Alleviates Temporal Lobe Epilepsy (\n                    <scp>TLE<\/scp>\n                    ) by Limiting Neuronal Ca\n                    <sup>2+<\/sup>\n                    Overload Through the\n                    <scp>HSPA1A<\/scp>\n                    \u2013\n                    <scp>AP2B1<\/scp>\n                    Axis"],"prefix":"10.1002","volume":"32","author":[{"given":"Zixiao","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6382-2772","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Harbin Medical University  Harbin Heilongjiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5346-7098","authenticated-orcid":false,"given":"Jiahang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"issue":"13","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/jama.2022.3880","article-title":"Antiseizure Medications for Adults With Epilepsy: A Review","volume":"327","author":"Kanner A. 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