{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:53:05Z","timestamp":1790959985996,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize eye\u2010tracking alterations across the depressive spectrum and evaluate their value for diagnostic stratification and symptom severity estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 183 participants completed a multi\u2010paradigm eye\u2010tracking battery. Group differences and associations with 17\u2010item Hamilton Depression Rating Scale (HAMD\u201017) scores were examined with multiple\u2010comparison correction and covariate adjustment. Classification, regression, and multi\u2010task models used repeated nested resampling with fold\u2010specific preprocessing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      False discovery rate (FDR)\u2010significant between\u2010group differences were observed for two first\u2010fixation latency measures from lateral\u2010gaze orienting and for antisaccade accuracy. Among 35 candidate features, 33 had covariate\u2010adjusted group associations at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. Across 539 retained features, covariate\u2010adjusted generalized additive models identified eight FDR\u2010significant associations with HAMD\u201017. In multi\u2010task analysis, Route B had numerically higher mean internal performance than Route A, although paired between\u2010route differences were imprecisely estimated (accuracy, 0.929 vs. 0.864; macro F1, 0.928 vs. 0.859; R\n                      <jats:sup>2<\/jats:sup>\n                      , 0.834 vs. 0.596). Regression\u2010only performance was similar to Route B (R\n                      <jats:sup>2<\/jats:sup>\n                      , 0.847).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eye\u2010tracking alterations spanned the depressive spectrum and were associated with symptom severity after covariate adjustment. Between\u2010route differences were imprecisely estimated, and joint\u2010task training showed no clear improvement in severity estimation. External and temporal validation are required before clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71198","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:00:58Z","timestamp":1790956858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eye\u2010Tracking Phenotypes Across the Depressive Spectrum: Joint Modeling of Diagnostic Group and Symptom Severity"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-3156","authenticated-orcid":false,"given":"Xiangting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of General Medicine The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital)  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0576-4538","authenticated-orcid":false,"given":"Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital)  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/jamapsychiatry.2023.5083","article-title":"A Systematic Evaluation of Machine Learning\u2010Based Biomarkers for Major Depressive Disorder","volume":"81","author":"Winter N. 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