{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:49Z","timestamp":1791625789307,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503804"],"award-info":[{"award-number":["2022YFC2503804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001234"],"award-info":[{"award-number":["82001234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271489"],"award-info":[{"award-number":["82271489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971203"],"award-info":[{"award-number":["81971203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801287"],"award-info":[{"award-number":["81801287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016101","name":"Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Neuroinflammation is a key pathogenic mechanism in temporal lobe epilepsy, quantifiable in\u00a0vivo using positron emission tomography targeting the translocator protein. This study integrated [\n                      <jats:sup>18<\/jats:sup>\n                      F]DPA\u2010714 PET\/MRI with serum cytokine profiling to investigate this central\u2013peripheral immune relationship in TLE patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective study of 24 TLE patients and 24 healthy controls (HCs) was conducted. PET\/MRI data were available for 24 TLE patients and 7 HCs, while cytokine data were available for all 24 participants in both groups. Standardized uptake value ratios of [\n                      <jats:sup>18<\/jats:sup>\n                      F]DPA\u2010714 were calculated for key temporal lobe regions. Serum levels of IL\u20102, IL\u20104, IL\u20106, IL\u201010, IL\u201017, TNF\u2010\u03b1, and IFN\u2010\u03b3 were quantified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, TLE patients demonstrated significantly increased [\n                      <jats:sup>18<\/jats:sup>\n                      F]DPA\u2010714 PET\/MRI uptake in ipsilateral temporal lobe structures (group main effect:\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>1,29<\/jats:sub>\n                      \u2009=\u200915.779,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), accompanied by a proinflammatory serum profile with elevated IL\u201017 and IFN\u2010\u03b3 and decreased IL\u20102, IL\u20104, and IL\u201010 levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Ipsilateral hippocampal [\n                      <jats:sup>18<\/jats:sup>\n                      F]DPA\u2010714 SUVR was positively correlated with disease duration (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025) and seizure frequency (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). However, no significant associations were observed between neuroimaging\u2010assessed central neuroinflammation and serum\u00a0cytokines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]DPA\u2010714 PET\/MRI precisely demonstrates focal neuroinflammation in TLE patients, correlating with clinical severity, yet the lack of correlation with peripheral markers highlights that peripheral and central immune responses represent distinct and relatively independent inflammatory processes in TLE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71200","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:11:39Z","timestamp":1791623499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction Between Peripheral Cytokines and Central Neuroinflammation in Temporal Lobe Epilepsy"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-6975","authenticated-orcid":false,"given":"Heyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou 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Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1745-9321","authenticated-orcid":false,"given":"Yicong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou 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Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-3423","authenticated-orcid":false,"given":"Guanzhong","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology  Guangzhou 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