{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T10:48:29Z","timestamp":1791629309541,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) is a severe, often enduring disorder with scarce biological treatments, largely unable to address its core implicit features: habit\u2010like food restriction and body\u2010experience disturbances. We report a single\u2010case application of resting\u2010state connectivity\u2010guided intermittent theta\u2010burst stimulation (iTBS) to the posterior parietal cortex (PPC), a hub for body representation, peripersonal space, and affordance\u2010based action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 31\u2010year\u2010old woman with 12\u2009years of treatment\u2010resistant restricting AN, enrolled in an ongoing sham\u2010controlled feasibility trial, underwent 20 active iTBS sessions to an individualized left\u2010PPC site maximally coupled with a body\u2010representation \u00d7 affordance reference network, assessed at baseline, post\u2010treatment, and four\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The protocol was fully feasible and well tolerated, without significant adverse events. Clinical change was gradual, with most of the weight gain occurring after the stimulation period: BMI rose from 15.65 to 16.01 at four\u2010month follow\u2010up and 16.40 over subsequent clinical follow\u2010up. Blinded global improvement was minimal; anxiety fell below threshold, whereas eating\u2010disorder and body\u2010shape scores remained at floor. Target\u2013reference connectivity increased in the a priori direction, toward the healthy\u2010control mean. Exploratory measures changed heterogeneously, only partly tracking engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case supports the feasibility and mechanistic plausibility of individualized parietal targeting in enduring AN, motivating a controlled trial to test its efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The parent trial is registered on\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT07106645)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71206","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:50:15Z","timestamp":1791625815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Connectivity\u2010Guided Individualized\n                    <scp>iTBS<\/scp>\n                    of the Posterior Parietal Cortex in Enduring Anorexia Nervosa: Network\u2010Level Target Engagement and Multimodal Response in a Single Case"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-1778","authenticated-orcid":false,"given":"Enrico","family":"Collantoni","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of Padua  Padova Italy"},{"name":"Padua Neuroscience Center University of Padua  Padova 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