{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:45:21Z","timestamp":1791963921615,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471471"],"award-info":[{"award-number":["82471471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with chronic temporal lobe epilepsy (TLE) frequently experience various sleep disorders, characterized by reduced sleep duration, diminished sleep stages, and disrupted sleep patterns. Recent research has identified a population of GABAergic neurons in the ventral zona incerta (ZI) that is instrumental in promoting sleep, along with a neural pathway that connects the cerebellar dentate nucleus (CDN) to the ZI. However, the precise role of this circuit in regulating sleep patterns remains inadequately understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study employed anatomical, chemogenetic, optogenetic, and immunofluorescence staining techniques to investigate the potential of the CDN\u2010ZI circuit in ameliorating sleep disturbances associated with TLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings indicate that pilocarpine\u2010treated mice exhibit significant sleep fragmentation and reduced sleep duration, particularly during non\u2010rapid eye movement sleep. By employing optogenetic and chemogenetic methods to target CDN glutamatergic neurons, we observed a decrease in sleep fragmentation, an increase in overall sleep duration, and an enhancement in sleep quality in pilocarpine\u2010treated mice. The inhibition of the CDN\u2010ZI glutamatergic circuit through optogenetic and chemogenetic methods resulted in substantial improvements in sleep disturbances following TLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Targeting the CDN\u2010ZI glutamatergic circuit represents a promising therapeutic strategy for addressing sleep disorders resulting from chronic TLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71207","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:52:01Z","timestamp":1791960721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of Cerebellar Dentate Nucleus\u2010Zona Incerta Glutamatergic Circuit Improves Sleep Disturbances in Chronic Temporal Lobe Epilepsy Model"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1483-1107","authenticated-orcid":false,"given":"Liang","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"},{"name":"Department of Neurology The First Naval Force Hospital of Southern Theatre Command  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2282-5188","authenticated-orcid":false,"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0527-404X","authenticated-orcid":false,"given":"Yingchi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7689-5731","authenticated-orcid":false,"given":"Changgeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-2917","authenticated-orcid":false,"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108675","article-title":"Evaluation of Sleep Habits, Sleep Chronotype, and Quality of Life in Children With Drug\u2010Resistant Epilepsy in Turkey","volume":"130","author":"Oz B.","year":"2022","journal-title":"Epilepsy & Behavior"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107316","article-title":"Objectively Measured Sleep\u2010Wake Patterns in Patients With Drug\u2010Resistant Epilepsy \u2013 Interaction With Quality of Life and Antiepileptic Treatment","volume":"112","author":"Pavlova M. 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