{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:47:50Z","timestamp":1792172870391,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274650"],"award-info":[{"award-number":["82274650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CIZIA2024\u2010003"],"award-info":[{"award-number":["CIZIA2024\u2010003"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether electroacupuncture (EA) at Zusanli (ST36) ameliorates alcohol\u2010related cognitive impairment (ARCI) by restoring intestinal barrier integrity and to elucidate the role of the vagus nerve in this \u201cgut\u2010to\u2010brain\u201d protective mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An ARCI mouse model was established by daily ethanol gavage for 28\u2009days. Mice received EA at ST36 from day 15 onwards. Behavioral tests (MWM, OFT, EPM) were conducted to assess cognitive and emotional function. Time\u2010course analysis of intestinal pathology (H&amp;E, ZO\u20101), permeability (FITC\u2010LPS, DAO), and neuroinflammation (LPS, IBA\u20101, cytokines) was performed. The role of the vagus nerve was investigated using ipsilateral DMV lesion and exogenous LPS challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronic alcohol exposure caused significant cognitive deficits, anxiety\u2010like behaviors, and body weight loss, accompanied by early\u2010onset intestinal barrier disruption and elevated LPS, which preceded central neuroinflammation. EA at ST36 significantly ameliorated these behavioral and pathological changes. EA activated DMV cholinergic neurons, restored ZO\u20101 expression, and reduced LPS translocation. Crucially, both DMV lesion and exogenous LPS administration abolished EA's protective effects on the intestinal barrier, neuroinflammation, and behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EA at ST36 alleviates ARCI by activating the vagus nerve to restore intestinal barrier integrity, thereby preventing gut\u2010derived LPS from triggering neuroinflammation. This identifies a key vagal\u2010dependent mechanism and supports EA as a promising intervention for ARCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71213","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:10:35Z","timestamp":1792170635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture Ameliorates Alcohol\u2010Related Cognitive Impairment by Modulating the Gut\u2010Brain Axis to Alleviate\n                    <scp>LPS<\/scp>\n                    Driven Neuroinflammation"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0882-1185","authenticated-orcid":false,"given":"Yueqin","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"},{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1488-5593","authenticated-orcid":false,"given":"Jianjie","family":"Luo","sequence":"additional","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2456-0040","authenticated-orcid":false,"given":"Shuyou","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"},{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5344-4594","authenticated-orcid":false,"given":"Guangjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-0582","authenticated-orcid":false,"given":"Weiguo","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-285X","authenticated-orcid":false,"given":"Xiaojing","family":"Song","sequence":"additional","affiliation":[{"name":"Medical Engineering Laboratory, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"issue":"8","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/add.15023","article-title":"Alcohol Use Disorders and the Brain","volume":"115","author":"Rao R.","year":"2020","journal-title":"Addiction"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2217\/nmt-2016-0030","article-title":"Alcohol\u2010Related Cognitive Impairment: Current Trends and Future Perspectives","volume":"6","author":"Hayes V.","year":"2016","journal-title":"Neurodegenerative Disease Management"},{"issue":"2","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0280749","article-title":"Informing the Development of Diagnostic Criteria for Differential Diagnosis of Alcohol\u2010Related Cognitive Impairment (ARCI) Among Heavy Drinkers: A Systematic Scoping Review","volume":"18","author":"Manning V.","year":"2023","journal-title":"PLoS One"},{"issue":"5","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrneurol.2011.42","article-title":"Clinical and Pathological Features of Alcohol\u2010Related Brain Damage","volume":"7","author":"Zahr N. 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