{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:42:43Z","timestamp":1792590163377,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M782381"],"award-info":[{"award-number":["2025M782381"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate the role of glymphatic dysfunction in the association between stenosis and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Older adults from a longitudinal cohort underwent magnetic resonance angiography to quantify cerebral artery stenosis burden. Glymphatic function was evaluated using diffusion tensor imaging\u2010analysis along the perivascular space (DTI\u2010ALPS) and free water in white matter (FW\u2010WM). Global cognitive performance was assessed using the Mini\u2010Mental State Examination (MMSE) and the Clinical Dementia Rating\u2010Sum of Boxes (CDR\u2010SB). Mediation analyses examined indirect effects, and longitudinal cognitive outcomes were analyzed using linear mixed\u2010effects and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 346 participants, 87 (25.1%) had at least one stenotic cerebral artery. Stenosis burden was associated with a lower DTI\u2010ALPS index (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and higher FW\u2010WM (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). Both DTI\u2010ALPS and FW\u2010WM significantly mediated the association between stenosis burden and baseline MMSE, accounting for 13.06%\u201317.19% of the total effect. In longitudinal analyses, participants with stenosis and impaired glymphatic function had a higher risk of CDR\u2010SB worsening relative to those with stenosis but preserved glymphatic function (hazard ratios 1.35\u20132.96) and those without stenosis (hazard ratios 3.27\u20134.70).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that glymphatic dysfunction may contribute to the association between cerebral artery stenosis and cognitive deterioration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71216","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:03:17Z","timestamp":1792587797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community\u2010Dwelling Older Adults"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-497X","authenticated-orcid":false,"given":"Weizhuang","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China"},{"name":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China"},{"name":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-8350","authenticated-orcid":false,"given":"Linfang","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China"},{"name":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China"},{"name":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(24)00038\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)30029\u20101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003837"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22055"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043630"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000675\u20106"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.673440"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011666140302194358"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027887\u20100"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1546482"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007318\u20103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14453"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201300"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/367516"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","unstructured":"P. J.LaMontagne T. L.Benzinger J. C.Morris et\u00a0al. \u201cOASIS\u20103: Longitudinal Neuroimaging Clinical and Cognitive Dataset for Normal Aging and Alzheimer Disease \u201dmedRxiv 2019:2019.12.13.19014902 https:\/\/doi.org\/10.1101\/2019.12.13.19014902.","DOI":"10.1101\/2019.12.13.19014902"},{"issue":"4","key":"e_1_2_11_20_1","first-page":"643","article-title":"A Standardized Method for Measuring Intracranial Arterial Stenosis","volume":"21","author":"Samuels O. B.","year":"2000","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.22.6.711"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.12000"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.125.051719"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1154"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011292"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.041"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.681743"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241228203"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0321\u20102"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22055"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70104"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","unstructured":"E.Gibson J.Ramirez L. A.Woods et\u00a0al. \u201csegcsvdPVS: A Convolutional Neural Network\u2010Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T1\u2010Weighted Images \u201dmedRxiv 2025.07.29.25332360 https:\/\/doi.org\/10.1101\/2025.07.29.25332360.","DOI":"10.1002\/alz70856_104470"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.12.008"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.102"},{"issue":"2","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.2517-6161.1959.tb00346.x","article-title":"The Comparison of Regression Variables","volume":"21","author":"Williams E. J.","year":"1959","journal-title":"Journal of the Royal Statistical Society, Series B: Statistical Methodology"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082\u2010989X.12.4.399"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1232304"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.789918"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A9033"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29713"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.71216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:03:19Z","timestamp":1792587799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.71216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cns.71216"],"URL":"https:\/\/doi.org\/10.1002\/cns.71216","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71216"}}