{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:23:47Z","timestamp":1775251427449,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Child Neurology Society"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal autonomic signs such as apnea, cyanosis, pallor, and desaturation rarely occur as isolated ictal phenomena and require a high degree of clinical suspicion in combination with continuous video electroencephalogram (vEEG) to establish a diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We review the clinical profile, etiology, and treatment response in five neonates who presented with apnea as the primary seizure semiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ictal apneic episodes were confirmed on continuous vEEG in all five infants within 24\u201348\u2009h of symptom onset. Seizure etiologies included structural, infectious, and genetic, including a neonate with <jats:italic>ANKRD11<\/jats:italic>\u2010associated KBG syndrome, in which ictal apnea has not been previously described. Acute seizures resolved in all neonates following treatment with a single or combination of antiseizure medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abrupt onset and clustering episodes of apnea and oxygen desaturation in term infants should raise suspicion for epileptic seizures. Genetic testing should be considered as part of the diagnostic evaluation for autonomic seizures of unknown etiology. Early diagnosis and treatment of neonatal autonomic seizures may lead to excellent treatment response in the acute setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cns3.20046","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:56:00Z","timestamp":1700182560000},"page":"312-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical spectrum, etiology, and treatment response in neonatal autonomic seizures: A case series"],"prefix":"10.1002","volume":"1","author":[{"given":"Robin M.","family":"Litten","sequence":"first","affiliation":[{"name":"Le Bonheur Children's Comprehensive Epilepsy Center University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Le Bonheur Children's Comprehensive Epilepsy Center University of Tennessee 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