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Key features that characterize laminopathies include axial and proximal weakness, contractures, and cardiac abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Results<\/jats:title><jats:p>A 12\u2010year\u2010old girl diagnosed with juvenile dermatomyositis as a child presented with cardiac failure and was found to have an <jats:italic>LMNA<\/jats:italic> likely pathogenic variant, with a phenotype most consistent with Emery\u2013Dreifuss muscular dystrophy type 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The spectrum of clinical features of <jats:italic>LMNA<\/jats:italic>\u2010related muscular dystrophies can mimic or present with inflammatory myopathy\u2010like features. Early identification of <jats:italic>LMNA<\/jats:italic>\u2010related muscular dystrophies is crucial to ensure appropriate cardiac screening and prevent devastating cardiac complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cns3.20075","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:02:37Z","timestamp":1718622157000},"page":"242-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>LMNA<\/i>\u2010related muscular dystrophy presenting as an inflammatory myopathy"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3550-1263","authenticated-orcid":false,"given":"Alexandra Santana","family":"Almansa","sequence":"first","affiliation":[{"name":"Department of Neurology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Chrzanowski","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farrah","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Department of Genetics Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Day\u2010Lewis","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hart G. 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