{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:55:11Z","timestamp":1765878911005,"version":"3.48.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Child Neurology Society"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Accurate prediction of both favorable and unfavorable long\u2010term neurodevelopmental outcomes of neonatal hypoxic\u2010ischemic encephalopathy (HIE) is essential for clinical care, yet the brain structures underlying a favorable prognosis remain unclear. This study aimed to identify diffusion magnetic resonance imaging (MRI) measures that can predict the 2\u2010year outcomes in neonates with HIE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed whole\u2010brain diffusion MRI scans from a retrospective cohort of 40 neonates with HIE, acquired within 14 days of birth. Diffusion measures were quantified across 16 cerebrum regions covering the whole cerebrum. We used the area under the Receiver Operating Characteristic curve (AUC) to evaluate the performance of regional fractional anisotropy (FA) and mean diffusivity (MD) values in predicting neurodevelopmental outcomes assessed at 2 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reduced FA in the thalamus (AUC\u2009=\u20090.990), basal ganglia (AUC\u2009=\u20090.961), basal forebrain (AUC\u2009=\u20090.951), and limbic white matter (AUC\u2009=\u20090.961) strongly predicted severe disability or death, whereas preserved limbic white matter FA uniquely predicted favorable outcomes (AUC\u2009=\u20090.811).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While FA reduction in the thalamus, basal ganglia, and basal forebrain is a robust marker for severe outcomes, the limbic white matter demonstrated sensitivity to mild hypoxic\u2010ischemic injury. Therefore, the preservation can be a potential marker for predicting favorable neurodevelopmental trajectories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns3.70047","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T18:09:42Z","timestamp":1764353382000},"page":"308-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preserved Limbic White Matter Predicts Favorable 2\u2010Year Outcomes in Neonatal Hypoxic\u2010Ischemic Encephalopathy"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8216-2145","authenticated-orcid":false,"given":"Xingyu","family":"Chen","sequence":"first","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Biomedical Informatics and Data Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Tomoshige","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2440-9842","authenticated-orcid":false,"given":"Ria","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Neurology and Developmental Medicine Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera J.","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Neurology and Developmental Medicine Kennedy Krieger Institute Baltimore Maryland USA"},{"name":"Neuroscience Intensive Care Nursery Program Johns Hopkins Children's Center Baltimore Maryland USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwendolyn","family":"Gerner","sequence":"additional","affiliation":[{"name":"Neuroscience Intensive Care Nursery Program Johns Hopkins Children's Center Baltimore Maryland USA"},{"name":"Department of Neuropsychology Kennedy Krieger Institute Baltimore Maryland USA"},{"name":"Department of Psychiatry, School of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathanael","family":"Kuo","sequence":"additional","affiliation":[{"name":"Applied Physics Laboratory Johns Hopkins University Laurel Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill S.","family":"Chotiyanonta","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0788-8028","authenticated-orcid":false,"given":"Raul","family":"Chavez\u2010Valdez","sequence":"additional","affiliation":[{"name":"Neuroscience Intensive Care Nursery Program Johns Hopkins Children's Center Baltimore Maryland USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Gynecology &amp; Obstetrics Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances J.","family":"Northington","sequence":"additional","affiliation":[{"name":"Neuroscience Intensive Care Nursery Program Johns Hopkins Children's Center Baltimore Maryland USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Oishi","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.nainr.2011.07.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.783"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530938"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0545"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijri.IJRI_384_16"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1202-5"},{"key":"e_1_2_9_8_1","article-title":"Tract Integrity Predicts Neurological Outcomes in Neonatal Hypoxic\u2010Ischemic Encephalopathy","volume":"1","author":"Tsai P.","year":"2025","journal-title":"Pediatrics and Neonatology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.40"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70063"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0674-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.190421"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470919.2017.1386126"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.08.047"},{"volume-title":"Capute and Accardo's Neurodevelopmental Disabilities in Infancy and Childhood","year":"2024","author":"Ismail F. 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