{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:36:03Z","timestamp":1773776163000,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Child Neurology Society"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Tumefactive demyelinating lesions (TDLs) are large lesions (&gt;\u20092\u2009cm) seen in demyelinating syndromes such as multiple sclerosis, myelin oligodendrocyte glycoprotein antibody\u2010associated disorder, and neuromyelitis optica spectrum disorder. They rarely occur in children and most often have a monophasic course. TDLs can cause severe presentations given their size, edema, and associated mass effect, making prompt diagnosis and effective treatment crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Description<\/jats:title>\n                    <jats:p>We present four adolescents with TDLs who tested negative for aquaporin\u20104\u2010IgG and myelin oligodendrocyte glycoprotein (MOG)\u2010IgG and did not meet diagnostic criteria for any known demyelinating disorder. All four patients underwent extensive and inconclusive workup for the etiology of their radiographic and clinical findings and received multiple immunomodulators with some clinical improvement, although three of the four had multiple relapses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TDLs that do not meet criteria for the known demyelinating syndromes can cause significant neurological sequelae. We describe four adolescents with neurological symptoms associated with TDLs. Given the rare but serious occurrence of these non\u2010syndromic TDLs, more well\u2010powered studies are critical to guide diagnosis, management, and response to therapies and eventually develop evidence\u2010based protocols to manage other patients with similar presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns3.70055","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:09:27Z","timestamp":1768997367000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Syndromic Tumefactive Demyelinating Lesions in the Pediatric Population: Four Case Reports and Review of the Literature"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-6525","authenticated-orcid":false,"given":"Elizabeth C.","family":"Ballinger","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah F.","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Yarimi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Lotze","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita M.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen S.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-2941","authenticated-orcid":false,"given":"Alexander J.","family":"Sandweiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology and Developmental Neuroscience Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2024.05.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1092373"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000206820"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.868525"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.08.034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1052678"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-016-0626-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073819826225"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51844"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52048-w"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34420-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2017.10.026"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101460"}],"container-title":["Annals 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