{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:03:56Z","timestamp":1789567436068,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Child Neurology Society"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Little is known about shifting from pediatric to adult\u2010focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow\u2010up in the US pediatric\u2010onset MS (POMS) population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition\u2010of\u2010care practices. A cohort of POMS\/clinically isolated syndrome (CIS) at 12 US NPMSC sites was analyzed. The primary comparison was between &lt;\u200918 and \u2265\u200918\u2010years of age. The primary outcome was 1\u2010 and 2\u2010year lapse in last follow\u2010up visit, measured from last recorded database visit to data lock date or, if \u2265\u200918 years of age, up to 1 year after a patient reached their site's typical transition age, if earlier. Secondary outcomes were baseline factors associated with follow\u2010up lapse. The model was adjusted for preidentified confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with &lt;\u200918 years, age \u2265\u200918 was associated with greater hazard of 1\u2010 and 2\u2010year follow\u2010up lapse. In POMS\/CIS, the estimated hazard was 1.61 for 1\u2010year lapse (95% confidence interval [CI] 1.32\u20131.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 1.40 for 2\u2010year lapse (95% CI 1.11\u20131.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). In POMS\u2010only, the estimated hazard was 1.70 for 1\u2010year lapse (95% CI 1.33\u20132.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 1.49 for 2\u2010year lapse (95% CI 1.11\u20131.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Platform injectable disease\u2010modifying therapy was associated with greater and intravenous with lesser hazard of lapse in follow\u2010up, while MS was associated with lower hazard than CIS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Variable transition\u2010of\u2010care practices and barriers were reported by major US POMS centers. Before typical transition age, age \u2265\u200918 was associated with greater hazard of 1\u2010 and 2\u2010year follow\u2010up lapse than &lt;\u200918. Developing standardized, targeted transition\u2010of\u2010care practices in POMS may be important.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns3.70070","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:53:27Z","timestamp":1782392007000},"page":"177-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Healthcare Continuity in Pediatric\u2010Onset Multiple Sclerosis in the United States"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-5740","authenticated-orcid":false,"given":"Aaron W.","family":"Abrams","sequence":"first","affiliation":[{"name":"Department of Neurology Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Waltz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Race","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Charles","family":"Casper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gambrah\u2010Lyles","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in Saint Louis St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Neurology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Virupakshaiah","sequence":"additional","affiliation":[{"name":"Department of Neurology, UCSF Weill Institute for Neurosciences University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen S.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-9627","authenticated-orcid":false,"given":"Melissa A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey E.","family":"Poisson","sequence":"additional","affiliation":[{"name":"Department of Neurology Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Chava M.","family":"Bernfeld","sequence":"additional","affiliation":[{"name":"Department of Neurology Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Aaen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Loma Linda University San Bernardino California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Francisco","sequence":"additional","affiliation":[{"name":"Department of Neurology, UCSF Weill Institute for Neurosciences University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-7792","authenticated-orcid":false,"given":"Grace Y.","family":"Gombolay","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Healthcare of Atlanta Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Graves","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Krupp","sequence":"additional","affiliation":[{"name":"Department of Neurology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"Lotze","sequence":"additional","affiliation":[{"name":"Department of Neurology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soe","family":"Mar","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in Saint Louis St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Rensel","sequence":"additional","affiliation":[{"name":"Department of Neurology Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics University of Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neurology, Dell Children's Medical Center University of Texas Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Mendelt","family":"Tillema","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Weinstock\u2010Guttman","sequence":"additional","affiliation":[{"name":"Department of Neurology State University of New York at Buffalo Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Nursing University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Waubant","sequence":"additional","affiliation":[{"name":"Department of Neurology, UCSF Weill Institute for Neurosciences University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"US Network of Pediatric MS Centers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/1054-139X(93)90143-D"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000220"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200108000-00004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2008.00844.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsx142"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2008.00862.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsu028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-23384-6_7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508101933"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0120"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8060445"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0372-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f4d821"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.13304"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2014.09.088"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104123"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70093-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.505"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2013.06.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp278"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.04.009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036907.37650.8E"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa199"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814550656"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513484547"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2307\/3004028"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2026.103014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103052"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.01.052"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.325"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2021.09.008"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2018-063"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458505ms1206oa"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25737"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0083-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518754364"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70274-5"},{"issue":"3","key":"e_1_2_9_42_1","first-page":"S12","article-title":"Clinically Isolated Syndromes: Predicting and Delaying Multiple Sclerosis","volume":"68","author":"Thrower B. W.","year":"2007","journal-title":"Neurology"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511430704"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12030364"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2020.40"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104970"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000112"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519887328"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041227"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1135"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7349-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12327"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30306-7"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006471"}],"container-title":["Annals of the Child Neurology Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns3.70070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns3.70070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns3.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:10:02Z","timestamp":1789564202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns3.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cns3.70070"],"URL":"https:\/\/doi.org\/10.1002\/cns3.70070","archive":["Portico"],"relation":{},"ISSN":["2831-3267","2831-3267"],"issn-type":[{"value":"2831-3267","type":"print"},{"value":"2831-3267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}