{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:36:23Z","timestamp":1693197383936},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the hemodynamic effects of 2 short\u2010acting \u03b2<jats:sub>1<\/jats:sub>\u2010blockers, landiolol and esmolol, in the continuous presence of dobutamine in a prospective, single\u2010center, randomized, crossover study in 16 healthy White volunteers. Dobutamine was infused at a rate sufficient to increase the heart rate by at least 30 beats per minute, followed by a 60\u2010minute infusion of 50 \u03bcg\/kg\/min esmolol or 10 \u03bcg\/kg\/min landiolol on top of the unchanged dobutamine infusion. Concentrations of \u03b2\u2010blockers and their metabolites in blood, heart rate, and blood pressure were followed for 180 minutes. Landiolol reduced the dobutamine\u2010induced heart rate and blood pressure increases better than esmolol. After discontinuation of \u03b2\u2010blocker administration, heart rate recovered swiftly to preinfusion values in both study arms. Systolic and diastolic blood pressure recovered partially after landiolol but showed a continued reduction after esmolol. No serious adverse events were observed. The heart rate effect is characteristic for \u03b2\u2010blockers, whereas the blood pressure effects are likely due to direct and indirect \u03b2\u2010blocker effects as well as influences on various ion channels. This may explain why landiolol that is devoid of effects on renin and sodium, calcium, and potassium channels behaves different from esmolol with respect to blood pressure recovery.<\/jats:p>","DOI":"10.1002\/cpdd.1025","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T20:02:08Z","timestamp":1634760128000},"page":"309-317","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood Pressure Recovery After Dobutamine Antagonism: Partial With Landiolol, None With Esmolol"],"prefix":"10.1002","volume":"11","author":[{"given":"G\u00fcnther","family":"Krumpl","sequence":"first","affiliation":[{"name":"MRN Medical Research Network GmbH  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Ul\u010d","sequence":"additional","affiliation":[{"name":"Center for Pharmacology and Analysis (CEPHA) s.r.o.  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