{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:17:55Z","timestamp":1775672275276,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate the bioequivalence of two pazopanib tablet formulations in healthy Chinese subjects. A randomized, open\u2010label, single\u2010dose, two\u2010period, two\u2010sequence, crossover study was conducted under fasting conditions. A total of 32 eligible subjects were randomly administered a single dose of a 200\u2010mg generic or branded pazopanib tablet with a 16\u2010day washout period. Blood samples were collected before and up to 72\u00a0hours after dosing. Pharmacokinetic parameters were analyzed with noncompartmental analysis. Safety assessments included physical examinations, laboratory tests, and adverse events reporting. Maximum plasma concentration (C<jats:sub>max<\/jats:sub>), area under the plasma concentration\u2013time curve (AUC) from zero to the last quantifiable concentration (AUC<jats:sub>0\u2010t<\/jats:sub>), and AUC from zero to infinity (AUC<jats:sub>0\u2010\u221e<\/jats:sub>) were similar between the generic and branded products (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). The 90% confidence intervals of the geometric mean ratio of the test\/reference products for C<jats:sub>max<\/jats:sub>, AUC<jats:sub>0\u2010t<\/jats:sub>, and AUC<jats:sub>0\u2010\u221e<\/jats:sub> were 89.1%\u2013117.1%, 81.9%\u2013108.5%, and 82.4%\u2013109.6%, respectively. There were no serious adverse events during the study. The newly developed generic pazopanib tablet was bioequivalent to the reference product under fasting conditions. Both formulations were well tolerated in healthy Chinese volunteers.<\/jats:p>","DOI":"10.1002\/cpdd.1096","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T05:54:05Z","timestamp":1649224445000},"page":"1110-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics and Bioequivalence of a Generic and a Branded Pazopanib Tablet in Healthy Chinese Subjects"],"prefix":"10.1002","volume":"11","author":[{"given":"Lihua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Third Hospital of Changsha  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Hospital of Changsha  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd  Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Hospital of Changsha  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Hospital of Changsha  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Hospital of Changsha  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqing","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Hospital of Changsha  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keli","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Clinical Tech Laboratories Inc.  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