{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:13:18Z","timestamp":1723050798735},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573505"],"award-info":[{"award-number":["81573505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meal timings and content related to gallbladder emptying in the enterohepatic circulation are important for explaining the high variability in mycophenolic acid exposure. The limited sampling strategy (LSS) was established to estimate the area under the plasma concentration\u2013time curve from time 0 to 12 hours (AUC<jats:sub>0\u201012h<\/jats:sub>) of mycophenolic acid in therapeutic drug monitoring. The aim of this study is to investigate the effect of meal timings and content on the AUC<jats:sub>0\u201012h<\/jats:sub> of mycophenolic acid and to assess the influence of meals on LSS. A mycophenolic acid pharmacokinetic model with a mechanism\u2010based enterohepatic circulation process was employed to perform simulations under various assumed meal scenarios. The simulations were compared to evaluate the effect of meal timings and meal content on mycophenolic acid AUC<jats:sub>0\u201012h<\/jats:sub>. Monte Carlo simulations were performed using the meal parameter with the greatest impact on mycophenolic acid AUC<jats:sub>0\u201012h<\/jats:sub> as a variable. The corresponding LSS equations were established, and the predictive performance was assessed. Both the meal timings and meal content affected the mycophenolic acid AUC<jats:sub>0\u201012h<\/jats:sub>, and the postdose fasting period had the greatest impact. The predictive performance of the LSS is sensitive to the postdose fasting period. Therefore, meal timings may improve the estimation of mycophenolic acid AUC<jats:sub>0\u201012h<\/jats:sub> and the efficacy of therapeutic drug monitoring.<\/jats:p>","DOI":"10.1002\/cpdd.1141","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T05:18:35Z","timestamp":1662009515000},"page":"1331-1340","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Meal Timings and Meal Content on the AUC<sub>0\u201012h<\/sub> of Mycophenolic Acid: A Simulation Study"],"prefix":"10.1002","volume":"11","author":[{"given":"Lixuan","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Pharmacy Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingkang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92534-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746010-00002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1468068"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0039-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015828802490"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120330501400102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199834060-00002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2021.101756"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13997"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.8.775"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2016.1170806"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13121991"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002762"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000799"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318186f98a"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2011.01.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-021-00713-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.12.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M511"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181fc8fbb"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26123723"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01058903"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-018-0535-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536640-000000000-00000"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12152"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(99)70012-3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241100-00005"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03109.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31815f5416"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000360"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600690408"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600731013"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600740228"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85174-w"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.03636.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1064"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00340"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991776831"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-009-9136-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1771-1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140010-00002"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12048"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2014.06.354"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0284-x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2016.1157600"},{"issue":"2","key":"e_1_2_9_47_1","first-page":"157","article-title":"Normal values of gallbladder ejection fraction using 99mTc\u2010sestamibi scintigraphy after a fatty meal formula","volume":"16","author":"Kakhki VR","year":"2007","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13420"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2014.07.223"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.115.153866"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000913"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105578"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0215-y"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200004000-00005"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.02039.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.tb00415.x"}],"container-title":["Clinical Pharmacology in Drug Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpdd.1141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpdd.1141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpdd.1141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T09:50:50Z","timestamp":1692611450000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/cpdd.1141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/cpdd.1141"],"URL":"https:\/\/doi.org\/10.1002\/cpdd.1141","archive":["Portico"],"relation":{},"ISSN":["2160-763X","2160-7648"],"issn-type":[{"value":"2160-763X","type":"print"},{"value":"2160-7648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}