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A single dose of 2000\u00a0mg of test or reference capecitabine (Xeloda, Hoffmann\u2013La Roche) was orally administered postprandially. After 24\u00a0hours of washout, the patients were administered the test or the reference capecitabine alternately. PK samples were taken at the time of predose up to 6\u00a0hours postdose. Bioequivalence evaluation was performed using the geometric mean ratios of peak concentration in plasma (C<jats:sub>max)<\/jats:sub>, area under the concentration\u2010time curve from time 0 to 6 h (AUC<jats:sub>0\u2010t)<\/jats:sub>, and area under the concentration\u2010time curve from time 0 to infinity (AUC<jats:sub>0\u2010\u221e<\/jats:sub>) for capecitabine and 5\u2010fluorouracil (5\u2010FU). In this study, 90% confidence intervals of test\/reference mean ratios of C<jats:sub>max<\/jats:sub>, AUC<jats:sub>0\u2010t<\/jats:sub>, AUC<jats:sub>0\u2010\u221e<\/jats:sub> of capecitabine and 5\u2010FU were in the range of 80%\u2013125%. Both the test and reference capecitabine regimens were well tolerated in this study. Furthermore, we found that patients with esophageal\u2010gastrointestinal cancers had higher exposure to capecitabine and a shorter time to C<jats:sub>max<\/jats:sub> (T<jats:sub>max)<\/jats:sub> than those with breast cancer. In conclusion, a single oral dose of 2000\u00a0mg of test capecitabine tablets after postprandial administration was bioequivalent to the reference drug.<\/jats:p>","DOI":"10.1002\/cpdd.1202","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:13:52Z","timestamp":1673849632000},"page":"324-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics and Comparative Bioavailability of Test or Reference Capecitabine and Discrepant Pharmacokinetics Among Various Tumors in Chinese Solid Cancer Patients"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaoyu","family":"Li","sequence":"first","affiliation":[{"name":"Clinical Trial Center National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyang","family":"Cui","sequence":"additional","affiliation":[{"name":"Jiangsu Hengrui Medicine Co. 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