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In this single\u2010center, randomized, single\u2010dose, 2\u2010cycle, fasting\u2010dose BE study, HVs (n\u00a0=\u00a024) were 1:1 divided into 2 groups (test [T]\u2013reference [R] and R\u2013T) and received 6\u00a0mg\/kg of voriconazole intravenously with a 7\u2010day washout. The plasma was collected for up to 72\u00a0hours at the time point after dosing on day 1\/day 8. The plasma concentration of voriconazole was measured by liquid chromatography\u2013tandem mass spectrometry. Pharmacokinetic parameters were ascertained on the basis of a noncompartmental model. In the BE study, the geometric mean ratios of the maximum concentration, area under the concentration\u2013time curve from time 0 to the last measurable plasma concentration, and area under the concentration\u2013time curve from time 0 to infinity were 101.1%, 105.6%, and 105.5%, respectively, and the 90%CI fell within 80%\u2013125%. Adverse events were observed in 26.1% of subjects in the T formulation stage and 17.4% in the R formulation stage. Under the BE study, voriconazole values from T and R formulations were bioequivalent.<\/jats:p>","DOI":"10.1002\/cpdd.1218","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T07:29:55Z","timestamp":1676359795000},"page":"542-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Pharmacokinetics and Safety With Bioequivalence of Voriconazole Injection of 2 Formulations in Chinese Healthy Volunteers: Bioequivalence Study"],"prefix":"10.1002","volume":"12","author":[{"given":"Chunqi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The Second Affiliated Hospital of Zhejiang Chinese Medical University Xinhua Hospital of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danqing","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Laboratory 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