{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:06:21Z","timestamp":1760043981949},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Clindamycin 1%\/benzoyl peroxide 3% fixed\u2010dose combination gel (CLDM\/BPO3%) is a topical product for the treatment of acne vulgaris. In this study, plasma and urine concentrations of benzoic acid (BA) and hippuric acid (HA) were analyzed to estimate the pharmacokinetics (PK) of BPO after application of CLDM\/BPO3% twice\u2010daily for 7 days in Japanese patients with acne vulgaris. Seven\u2010day repeated application of CLDM\/BPO3% appears to be safe in this patient population. Concentrations of plasma and urine BA were below the limit of quantification before and after repeated application in most of the 12 adult male patients. Mean difference in C<jats:sub>max<\/jats:sub> and AUC<jats:sub>0\u2013last<\/jats:sub> for plasma HA indicated increased exposures after repeated application, but with wide 90% confidence intervals. Mean Ae<jats:sub>0\u201312<\/jats:sub> for urine HA was similar before and after repeated application. Repeated application of CLDM\/BPO3% is thus unlikely to result in accumulation of BA and HA. The study suggests negligible systemic exposure to BPO metabolites from CLDM\/BPO3% after 7\u2010day repeated application in male patients with acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cpdd.125","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T10:52:58Z","timestamp":1396435978000},"page":"18-24","source":"Crossref","is-referenced-by-count":1,"title":["Systemic exposure to benzoic acid and hippuric acid following topical application of clindamycin 1%\/benzoyl peroxide 3% fixed\u2010dose combination gel in Japanese patients with acne vulgaris"],"prefix":"10.1002","volume":"4","author":[{"given":"Hiroko","family":"Ino","sequence":"first","affiliation":[{"name":"GlaxoSmithKline K.K. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline K.K. 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