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In this study, <jats:italic>H. pylori<\/jats:italic> patients (426) were enrolled and randomized into 3 groups: an EA14 group (20\u00a0mg of esomeprazole qid\u00a0and 1000\u00a0mg of amoxicillin tid for 14 days), a VA14 group (20\u00a0mg of vonoprazan bid and 750\u00a0mg of amoxicillin qid for 14 days), and a VA10 group (20\u00a0mg of vonoprazan bid and 1000\u00a0mg of amoxicillin tid for 10 days). Key outcomes encompassed the <jats:italic>H. pylori<\/jats:italic> eradication rate, patient adverse effects, and compliance. In the EA14, VA14, and VA10 groups, <jats:italic>H. pylori<\/jats:italic> eradication rates were 89.4%, 90.1%, and 88.7% in intention\u2010to\u2010treat analysis, and 94.2%, 94.4%, and 94.6% in per\u2010protocol analysis, respectively. Adverse events incidences were 14.8%, 12.7%, and 5.6%, while compliance rates were 88.7%, 90.9%, and 95.8%, respectively. Notably, the VA10 regimen demonstrated comparable <jats:italic>H. pylori<\/jats:italic> eradication rates, adverse effect incidences, and compliance levels to the EA14 and VA14 regimens.<\/jats:p>","DOI":"10.1002\/cpdd.1357","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:38:25Z","timestamp":1704901105000},"page":"240-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Study on the Eradication of <i>Helicobacter pylori<\/i> by Vonoprazan Combined with Amoxicillin for 10\u2010Day Dual Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Kunfeng","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Taixing People's Hospital  Taixing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Taixing 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