{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:48:11Z","timestamp":1774039691439,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multimodal analgesia is defined as using several drugs or techniques simultaneously to target different pain pathways or receptors to avoid pain propagation. This study evaluated the pharmacokinetic profile and comparative bioavailability of etoricoxib 90\u00a0mg and tramadol 50\u00a0mg dosing alone (reference drugs) or in a novel fixed\u2010dose combination (test drug) under fasting conditions in Mexican healthy volunteers. This was a randomized, open\u2010label, 3\u2010way, crossover, single\u2010dose, prospective, and longitudinal study with a 14\u2010day washout period. Eligible subjects were healthy Mexican adult volunteers. The drugs were dosing orally, according to the randomization sequence, after 10\u00a0hours of fasting and 4\u00a0hours before breakfast with 250\u00a0mL of water at room temperature. Serial blood samples were collected before and after dosing, both drugs were quantified using high\u2010performance liquid chromatography coupled with tandem mass spectrometry. Forty\u2010two subjects were enrolled and 38 completed the study (28 men and 14 women, mean age 25.2\u00a0years, mean weight 66.6\u00a0kg). Test products were considered to have comparative bioavailability if confidence intervals of natural log\u2010transformed for (maximum plasma drug concentration (C<jats:sub>max<\/jats:sub>), (area under the plasma drug concentration\u2010time curve form 0 up to last sampling time (AUC<jats:sub>0\u2010t<\/jats:sub>), and (area under the plasma drug concentration\u2010time curve from 0 up to infinity (AUC<jats:sub>0\u2010\u221e<\/jats:sub>) data were within the range of 80%\u2010125%. Non\u2010serious adverse events were observed. The results demonstrate that the pharmacokinetic profile and bioavailability of the etoricoxib\/tramadol fixed\u2010dose combination are comparable to those of the reference products.<\/jats:p>","DOI":"10.1002\/cpdd.1456","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T08:31:55Z","timestamp":1722414715000},"page":"1253-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Bioavailability of a Novel Fixed\u2010dose Combination Etoricoxib and Tramadol"],"prefix":"10.1002","volume":"13","author":[{"given":"Lourdes","family":"Garza\u2010Oca\u00f1as","sequence":"first","affiliation":[{"name":"Pharmacology and Toxicology Department Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian T.","family":"Badillo\u2010Castaneda","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L. Montoya","family":"Egu\u00eda","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"Zanatta\u2010Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia D. Torres","family":"Garza","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Vinicio","family":"G\u00f3mez\u2010Meza","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 G.","family":"Sander\u2010Padilla","sequence":"additional","affiliation":[{"name":"Research and Development Department Laboratorios Silanes S.A. de C.V Mexico City 11000 Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Lugo\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Research and Development Department Laboratorios Silanes S.A. de C.V Mexico City 11000 Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F.","family":"Rios\u2010Brito","sequence":"additional","affiliation":[{"name":"Research and Development Department Laboratorios Silanes S.A. de C.V Mexico City 11000 Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Romero\u2010Antonio","sequence":"additional","affiliation":[{"name":"Research and Development Department Laboratorios Silanes S.A. de C.V Mexico City 11000 Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Gonz\u00e1lez\u2010Canudas","sequence":"additional","affiliation":[{"name":"Research and Development Department Laboratorios Silanes S.A. de C.V Mexico City 11000 Mexico"},{"name":"Instituto Mexicano del Seguro Social Centro M\u00e9dico Nacional Siglo XXI Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.085"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0898"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2022.04.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.10.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15070827"},{"issue":"4","key":"e_1_2_8_7_1","article-title":"Effects of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) and gastroprotective NSAIDs on the gastrointestinal tract: a narrative review","volume":"15","author":"Sohail R","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_8_1","first-page":"43","article-title":"Pharmacokinetic equivalence study of nonsteroidal anti\u2010inflammatory drug etoricoxib","volume":"10","author":"Tjandrawinata RR","year":"2018","journal-title":"Clin Pharmacol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15112569"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01515-z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.119156"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443130-00004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-021-00239-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03191172"},{"issue":"11","key":"e_1_2_8_15_1","first-page":"617","article-title":"Pharmacokinetic and bioequivalence study of etoricoxib tablet in healthy Bangladeshi volunteers","volume":"61","author":"Shohag MH","year":"2011","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_8_16_1","unstructured":"WinNonlin 6.03.Corporation. 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