{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:02:47Z","timestamp":1775671367226,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Itepekimab, a monoclonal antibody against interleukin\u201033, has demonstrated clinical utility in previous studies in patients with asthma and chronic obstructive pulmonary disease. An autoinjector (AI) has been developed for administering itepekimab to facilitate further development. This study compared pharmacokinetics of single 300\u2010mg itepekimab subcutaneous administration via an AI versus a prefilled syringe (PFS). Of 90 healthy volunteers enrolled in this Phase 1, parallel\u2010design, randomized study and stratified by body weight (50 to &lt;70\u00a0kg, \u226570 to &lt;80\u00a0kg, \u226580 to 100\u00a0kg) and injection site (abdomen, thigh, or arm), 84 completed the study. Systemic exposure of itepekimab was similar for both groups. Point estimates for geometric mean ratios of pharmacokinetic parameters for AI versus PFS groups were 1.01 for maximum serum concentration, 1.06 for area under the serum concentration\u2010time curve to the last quantifiable concentration, and 1.04 for area under the serum concentration\u2010time curve extrapolated to infinity. The exposure was similar for both devices in each body weight and injection site subgroup. Overall, systemic exposure of 300\u2010mg single\u2010dose itepekimab in healthy participants was comparable when administered subcutaneously via an AI device and PFS, with an acceptable safety profile in both device groups.<\/jats:p>","DOI":"10.1002\/cpdd.1466","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T07:58:38Z","timestamp":1727078318000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetics of Subcutaneous Itepekimab Injection With an Autoinjector Device and Prefilled Syringe in Healthy Participants"],"prefix":"10.1002","volume":"13","author":[{"given":"Christine","family":"Xu","sequence":"first","affiliation":[{"name":"Sanofi  Bridgewater NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kong","family":"Xin","sequence":"additional","affiliation":[{"name":"Sanofi  Beijing 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