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To establish bioequivalence between the test and reference products of fluticasone propionate nasal spray, an open\u2010label, randomized, single\u2010dose, and 2\u2010sequence crossover study was conducted on 84 healthy Chinese subjects under fasting conditions to determine the pharmacokinetic bioequivalence of the 2 products. Following a single\u2010dose administration (200\u00a0\u00b5g) of fluticasone propionate nasal spray, pharmacokinetic parameters, including maximum plasma concentration, area under the concentration\u2013time curve from administration to the last measurable concentration, and area under the concentration\u2013time curve from administration to infinity, exhibited similarity between the 2 products, with 90% confidence intervals for the test\/reference ratios falling within the bioequivalence range of 80%\u2010125%.<\/jats:p>","DOI":"10.1002\/cpdd.1507","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T05:40:46Z","timestamp":1737351646000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics and Bioequivalence of 2 Products of Fluticasone Propionate Nasal Spray in Healthy Chinese 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