{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:40:10Z","timestamp":1756798810032,"version":"3.44.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A fixed\u2010dose combination (FDC) tablet formulation of donepezil\/memantine (10\/20\u00a0mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil\/memantine [10\/20\u00a0mg]) and single components (SCs) of donepezil (10\u00a0mg) and memantine (20\u00a0mg). In a randomized, open\u2010label, single\u2010dose, 2\u2010way crossover study, 24 healthy Korean participants received a single oral dose of FDC in 1 period and an SC of donepezil and memantine in another period. For PK analysis, blood samples were collected up to 240\u00a0hours after administration. The geometric mean ratios and their 90% confidence intervals for the main PK parameters (C<jats:sub>max<\/jats:sub> and AUC<jats:sub>last<\/jats:sub>) indicated PK equivalence between the FDC and SC formulations. Regarding the safety profile, all adverse events were mild, with no serious adverse events. These findings support the use of an FDC formulation as a viable alternative to SCs of donepezil and memantine, potentially improving treatment adherence in patients with moderate\u2010to\u2010severe AD.<\/jats:p>","DOI":"10.1002\/cpdd.1556","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:36:07Z","timestamp":1748586967000},"page":"710-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioequivalence of a Donepezil\/Memantine 10\/20\u00a0mg Fixed\u2010Dose Combination Versus Single\u2010Component Tablets in Healthy Korean Males"],"prefix":"10.1002","volume":"14","author":[{"given":"Minkyu","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Severance Hospital Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Pharmaceutical Medicine and Regulatory Sciences Colleges of Medicine and Pharmacy Yonsei University Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Hak","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Severance Hospital Yonsei University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoon","family":"Keum","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Severance Hospital Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Pharmaceutical Medicine and Regulatory Sciences Colleges of Medicine and Pharmacy Yonsei University Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Hoon","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Severance Hospital Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Pharmaceutical Medicine and Regulatory Sciences Colleges of Medicine and Pharmacy Yonsei University Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Severance Hospital Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Pharmaceutical Medicine and Regulatory Sciences Colleges of Medicine and Pharmacy Yonsei University Incheon South Korea"},{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Hyundai Pharmaceutical Co. Ltd. Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungjin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Hyundai Pharmaceutical Co. Ltd. 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