{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:11:59Z","timestamp":1776363119750,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, we assessed the pharmacokinetics, safety, and bioequivalence of trimetazidine tablets from 2 different manufacturers in healthy Chinese individuals under both fasting and fed conditions. Twenty\u2010eight healthy Chinese volunteers were included in each fasting and fed group. They were randomly assigned to fasting and fed arms in a single\u2010center, randomized, open\u2010label, crossover trial with a 2\u2010period, 2\u2010sequence design. Plasma trimetazidine levels were determined using liquid chromatography\u2010tandem mass spectrometry. Pharmacokinetic parameters were determined using a nonatrioventricular model. The pharmacokinetic parameters were obtained by the concentration\u2010time profiles, including the area under the plasma concentration\u2010time curve from time 0 to 24 hours, area under the concentration\u2010time curve from time 0 to infinity, maximum concentration, time to achieve maximum concentration, and elimination half\u2010life. Both trimetazidine preparations were bioequivalent under fasting and fed states, with all parameters within the acceptable limits. All recorded adverse events were mild. Overall, the test trimetazidine formulation was bioequivalent to the reference formulation and safe for use in healthy Chinese subjects in both the fasting and fed states.<\/jats:p>","DOI":"10.1002\/cpdd.1582","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:50:43Z","timestamp":1754473843000},"page":"889-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Pharmacokinetics, Bioequivalence, and Safety of Two Preparations of 20\u2010mg Trimetazidine in Healthy Chinese Subjects"],"prefix":"10.1002","volume":"14","author":[{"given":"Dongmei","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fucai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xihua","family":"Fu","sequence":"additional","affiliation":[{"name":"Infection Medicine Research Institute of Panyu District The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuoheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Panyu Central Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4977209"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.08.034"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.02.85"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.702795"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.05.063"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.150839"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"9","article-title":"Quantitative structure\u2010activity relationship analysis of the substituent effects on the binding affinity of derivatives of trimetazidine","volume":"54","author":"Slavov S","year":"2004","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr038"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi816"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259609046702"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1180-4357"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02134-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9434-x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.985"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1211"},{"issue":"16","key":"e_1_2_11_17_1","first-page":"2477","article-title":"Bioequivalence of trimetazidine hydrochloride tablets in healthy Chinese volunteers","volume":"36","author":"Zhu Z","year":"2020","journal-title":"Chin J Clin Pharmacol"},{"issue":"21","key":"e_1_2_11_18_1","first-page":"2519","article-title":"Bioequivalence and pharmacokinetic study of trimetazidine dihydrochloride in human plasma by using LC\u2010MS\/MS","volume":"22","author":"Zhang J","year":"2013","journal-title":"Chin J New Drugs"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199958010-00016"},{"issue":"60","key":"e_1_2_11_20_1","first-page":"101","article-title":"Trimetazidine: a second look. 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