{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:26:36Z","timestamp":1789928796055,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["NCT00650910"],"award-info":[{"award-number":["NCT00650910"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The potential for an interaction between lapatinib and absorption of the P\u2010glycoprotein (ABCB1) substrate digoxin at a therapeutic dose in breast cancer patients was characterized. Seventeen women with HER2\u2010positive metastatic breast cancer received a single oral 0.5\u2010mg dose of digoxin on days 1 and 9 and oral lapatinib 1500 mg once daily on days 2 through 9. Digoxin pharmacokinetic parameters were determined on day 1 (digoxin administration alone) and on day 9 (coadministration of lapatinib and digoxin), and parameters were compared to determine the effects of lapatinib on digoxin absorption. Concomitant medications that could affect ABCB1 were accounted for. Lapatinib 1500\u2009mg\/day increased digoxin absorption approximately 80%, implicating lapatinib inhibition of intestinal ABCB1\u2010mediated efflux. In summary, coadministration of lapatinib with narrow therapeutic index drugs that are substrates of ABCB1 should be undertaken with caution and dose adjustment should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cpdd.189","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T20:04:29Z","timestamp":1427227469000},"page":"449-453","source":"Crossref","is-referenced-by-count":10,"title":["Effect of lapatinib on oral digoxin absorption in patients"],"prefix":"10.1002","volume":"4","author":[{"given":"Kevin M.","family":"Koch","sequence":"first","affiliation":[{"name":"GlaxoSmithKline Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Smith","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Botbyl","sequence":"additional","affiliation":[{"name":"Provonix, Inc. 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