{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:20:50Z","timestamp":1787955650131,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quantification of blood levels of antipsychotic drugs may be useful for managing medication therapy. This open\u2010label, parallel\u2010group study was performed to compare finger\u2010stick\u2010based capillary with corresponding venous plasma concentrations for risperidone, paliperidone, quetiapine, olanzapine, and aripiprazole and their major metabolites after repeated dosing in patients with schizophrenia or related illnesses. Finger\u2010stick\u2010based capillary and venous blood samples were collected at various times within a dosing interval. All drug concentration measurements in the derived plasma samples were performed with validated liquid chromatography\u2013tandem mass spectrometry methods. Finger\u2010stick\u2010based capillary and venous plasma drug concentrations after repeated dosing were generally similar. Olanzapine capillary plasma concentrations, however, were on average approximately 20% higher than venous concentrations, with a trend for a relatively greater difference occurring shortly after dosing. In addition, smaller capillary\u2013venous differences were observed for extended\u2010release and long\u2010acting intramuscular formulations and for aripiprazole, a drug with a long half\u2010life, compared with drugs administered as an immediate\u2010release formulation (risperidone, olanzapine). After repeated dosing, plasma derived from finger\u2010stick\u2010based blood was observed to be predictive of the venous concentrations. Capillary sampling may be an appropriate alternative to venous sampling to readily evaluate systemic drug concentrations.<\/jats:p>","DOI":"10.1002\/cpdd.291","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T10:39:54Z","timestamp":1467369594000},"page":"538-547","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Capillary and Venous Plasma Drug Concentrations After Repeated Administration of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole"],"prefix":"10.1002","volume":"5","author":[{"given":"Bart","family":"Remmerie","sequence":"first","affiliation":[{"name":"Janssen Research &amp; Development Division of Janssen Pharmaceutica NV  Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"De Meulder","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development Division of Janssen Pharmaceutica NV  Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Ariyawansa","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Savitz","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1286287"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-26"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110372817"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S42735"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201100084"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.7090su1cj"},{"issue":"16","key":"e_1_2_11_8_1","first-page":"3","article-title":"Overview of partial compliance","volume":"64","author":"Marder SR","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.11.002"},{"key":"e_1_2_11_10_1","first-page":"18","article-title":"Treatment adherence and insight in schizophrenia","volume":"30","author":"Bitter I","year":"2015","journal-title":"Psychiatr Hung"},{"key":"e_1_2_11_11_1","first-page":"541","article-title":"Skills\u2010based medication training program for patients with schizophrenic disorders: a rater\u2010blind randomized controlled trial","volume":"9","author":"Schirmer UB","year":"2015","journal-title":"Patient Prefer Adherence"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199712000-00006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3182577c43"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.11.022"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.05.013"},{"key":"e_1_2_11_16_1","article-title":"Comparison of capillary and venous drug concentrations after administration of a single dose of risperidone, paliperidone, quetiapine, olanzapine or aripirazole","author":"Remmerie B","year":"2016","journal-title":"Clin Pharmacol Drug Dev"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.15.100"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1093\/clinchem\/25.10.1837","article-title":"Comparison of theophylline concentrations in venous blood and capillary blood in asthmatic children","volume":"25","author":"Umstead GS","year":"1979","journal-title":"Clin Chem"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200010000-00015"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1985.tb05117.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.16.27"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.5.1024"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198917030-00004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198917040-00005"}],"container-title":["Clinical Pharmacology in Drug Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpdd.291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpdd.291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpdd.291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpdd.291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpdd.291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:23:33Z","timestamp":1696631013000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/cpdd.291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,17]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/cpdd.291"],"URL":"https:\/\/doi.org\/10.1002\/cpdd.291","archive":["Portico"],"relation":{},"ISSN":["2160-763X","2160-7648"],"issn-type":[{"value":"2160-763X","type":"print"},{"value":"2160-7648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,17]]}}}