{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:39:59Z","timestamp":1783085999962,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To investigate the predictive value of interleukin (IL)\u20104 and IL\u201021 levels in assessing disease activity score and antihistamine treatment response in chronic spontaneous urticaria (CSU) patients. One hundred and twenty CSU patients treated at our hospital between January 2023 and January 2025 were retrospectively selected as the study group. Eighty healthy individuals undergoing routine physical examinations during the same period were included as the control group. Serum IL\u20104 and IL\u201021 levels, and the proportion of peripheral blood follicular helper T (Tfh) cells within CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells were retrieved from the hospital information system. Based on the Urticaria Activity Score over 7 days (UAS7), CSU patients were divided into three subgroups: mild (UAS7 &lt; 16, n = 43), moderate (UAS7 16\u201027, n = 52), and severe (UAS7 \u2265 28, n = 25). All patients received standard antihistamine therapy for 4 weeks. According to treatment response, patients were categorized into four groups: complete remission, marked improvement, partial remission, and no response. The correlations of IL\u20104, IL\u201021, and Tfh cell levels with disease severity were analyzed, and their predictive value for CSU diagnosis and antihistamine treatment response was evaluated. IL\u20104 and IL\u201021 are co\u2010upregulated in CSU patients, and their levels increase with disease activity and are positively correlated with UAS7 score (r =\n.603, 0.314,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\n.001). These biomarkers have a certain reference value for diagnosis and severity assessment of CSU. Baseline levels of IL\u20104 and IL\u201021 may serve as predictive biomarkers for antihistamine treatment response, providing a potential reference for individualized treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/cpdd.70027","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:09:53Z","timestamp":1770455393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Significance of IL\u20104 and IL\u201021 Concurrent Elevation in Predicting Disease Activity Score and Antihistamine Treatment Response in Chronic Spontaneous Urticaria"],"prefix":"10.1002","volume":"15","author":[{"given":"Shining","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Hebei North University  Zhangjiakou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Hebei North University  Zhangjiakou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Hebei North University  Zhangjiakou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Hebei North University  Zhangjiakou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Hebei North University  Zhangjiakou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"An","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Hebei North University  Zhangjiakou Hebei 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role of circulating CD4(+)CXCR5(+) cell subpopulations in patients with chronic spontaneous urticarial","volume":"12","author":"Gao C","year":"2020","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.01.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02966-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02375E"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"225","article-title":"Effect of treatment with intranasal corticosteroid and oral antihistamine on cytokine profiles of peripheral blood mononuclear cells of patients with allergic rhinitis sensitive to chenopodium album","volume":"9","author":"Farrokhi S","year":"2010","journal-title":"Iran J Allergy Asthma Immunol"}],"container-title":["Clinical Pharmacology in Drug 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