{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:33:37Z","timestamp":1774362817014,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Pharm in Drug Dev"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Coenzyme Q10 (CoQ10) is a naturally occurring biochemical cofactor found in all human cell membranes in two interconvertible forms: oxidized ubiquinone and reduced ubiquinol. Clinical studies indicate that different CoQ10 formulations have different absorption rates, highlighting research comparing their systemic bioavailability. This study compared the oral bioavailability of cocrystal formulation soft gels (test product), a novel ubiquinol formulation, and ubiquinone formulation (reference product) in a randomized, double\u2010blind, two\u2010period crossover study with 12 healthy subjects under fasting conditions. The secondary objective of this study was to evaluate the safety and tolerability of the ubiquinol formulation. The pharmacokinetic analyses indicated that the test ubiquinol formulation demonstrated substantially higher relative systemic bioavailability compared with the ubiquinone reference. The geometric mean ratios (test\/reference) for baseline\u2010corrected peak plasma concentration (C\n                    <jats:sub>max<\/jats:sub>\n                    ) and area under the curve from zero to last quantifiable time (AUC\n                    <jats:sub>0\u2013t<\/jats:sub>\n                    ) were 2.20 and 2.01, respectively, with 90% confidence intervals of 1.59\u20133.04 and 1.51\u20132.70. The geometric mean ratio for AUC from time zero to infinity (AUC\n                    <jats:sub>0\u2013\u221e<\/jats:sub>\n                    ) was 3.43 (90% CI: 1.47\u20138.00). No adverse events were reported in this small pilot study for either of the formulations. These findings demonstrate that ubiquinol has a better systemic bioavailability than ubiquinone, supporting the novel formulation's potential as a promising alternative to traditional CoQ10 supplements.\n                  <\/jats:p>","DOI":"10.1002\/cpdd.70042","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:09:53Z","timestamp":1772968193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Randomized, Double\u2010Blind, Two\u2010Treatment, Two\u2010Period, Crossover Study Investigating the Systemic Bioavailability of a Novel Cocrystal Ubiquinol Formulation Compared with a Ubiquinone Formulation in Healthy Adults"],"prefix":"10.1002","volume":"15","author":[{"given":"Xuefeng","family":"Mei","sequence":"first","affiliation":[{"name":"Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Cocrystal Health Industry Co., Ltd  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kshitij","family":"Soni","sequence":"additional","affiliation":[{"name":"Credevo Pte. 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