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Both studies are random, single\u2010center, 2\u2010period, open\u2010label, 2\u2010way crossover designs. Plasma concentration of dapoxetine was determined by high\u2010performance liquid chromatography\u2013tandem mass spectrometry, and the pharmacokinetic parameters were calculated using noncompartmental analysis. Dapoxetine was quickly absorbed and reached maximum concentration 1 to 3 hours after oral administration. Elimination was biphasic, and the plasma concentration decreased to 3% to 7% of maximum concentration by 24 hours while half\u2010life was 15 to 18 hours. Meantime, high\u2010fat meals slightly increased its exposure. Both doses of dapoxetine were well tolerated. The adverse events in the high\u2010dose group under fasted and fed states were 37.9% and 19.0%, respectively.<\/jats:p>","DOI":"10.1002\/cpdd.919","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T09:54:37Z","timestamp":1612432477000},"page":"1216-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics and Safety of Dapoxetine Hydrochloride in Healthy Chinese Men: Impact of Dose and High\u2010Fat Meal"],"prefix":"10.1002","volume":"10","author":[{"given":"Jingyan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou 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