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Moreover, GLP\u20101 functions as a central nervous system peptide transmitter, produced by preproglucagon (\n                    <jats:italic>PPG<\/jats:italic>\n                    ) neurons in the hindbrain. Intestinal GLP\u20101 inhibits eating by activating vagal sensory neurons directly, via GLP\u20101 receptors (GLP\u20101Rs), but presumably also indirectly, by triggering the release of serotonin from enterochromaffin cells. GLP\u20101 enhances glucose\u2010dependent insulin release via a vago\u2010vagal reflex and by direct action on beta cells. Finally, intestinal GLP\u20101 acts on the kidneys to modulate electrolyte and water movements, and on the heart, where it provides numerous benefits, including anti\u2010inflammatory, antiatherogenic, and vasodilatory effects, as well as protection against ischemia\/reperfusion injury and arrhythmias. Hindbrain\n                    <jats:italic>PPG<\/jats:italic>\n                    neurons receive multiple inputs and project to many GLP\u20101R\u2010expressing brain areas involved in reward, autonomic functions, and stress.\n                    <jats:italic>PPG<\/jats:italic>\n                    neuron\u2010derived GLP\u20101 is involved in the termination of large meals and is implicated in the inhibition of water intake. This review details GLP\u20101's roles in these interconnected systems, highlighting recent findings and unresolved issues, and integrating them to discuss the physiological and pathological relevance of endogenous GLP\u20101 in coordinating these functions. As eating poses significant threats to metabolic, fluid, and immune homeostasis, the body needs mechanisms to mitigate these challenges while sustaining essential nutrient intake. Endogenous GLP\u20101 plays a crucial role in this \u201cingestive homeostasis.\u201d\n                  <\/jats:p>","DOI":"10.1002\/cph4.7","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T07:16:17Z","timestamp":1734938177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Glucagon\u2010Like Peptide\u20101 Links Ingestion, Homeostasis, and the Heart"],"prefix":"10.1002","volume":"15","author":[{"given":"Jean\u2010Philippe","family":"Krieger","sequence":"first","affiliation":[{"name":"Vetsuisse Faculty, Institute of Veterinary Pharmacology and Toxicology University of Zurich  Zurich Switzerland"},{"name":"Institute of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and the Center 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