{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:57:55Z","timestamp":1784980675321,"version":"3.55.0"},"reference-count":85,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Leptin, an adipokine primarily produced in white adipose tissue, plays a crucial role in metabolism, immunity, and inflammation. Originally identified as a satiety hormone, leptin is also synthesized in various tissues, including the lungs, where it regulates immune responses by binding to the ObR receptor and activating pathways like JAK\u2013STAT3 and PI3K. Functioning as a cytokine\u2010like hormone, leptin modulates innate and adaptive immunity by promoting T and B cell proliferation, macrophage activation, and chemokine secretion. In lung physiology, leptin contributes to maturation and alveolar development, but its role in acute lung disorders such as acute respiratory distress syndrome (ARDS) remains controversial. The \u201cobesity paradox\u201d suggests that obese patients may be protected against ARDS, potentially due to hyperleptinemia\u2010driven immune modulation, enhanced neutrophil recruitment, and improved alveolar macrophage function. However, obesity\u2010induced leptin resistance may impair these protective effects. Conflicting animal studies on leptin's role in acute lung injury (ALI) further complicate its understanding, with some showing protection and others increased susceptibility to lung damage. Further research is needed to clarify leptin's influence on lung inflammation and its interplay with metabolic disorders like obesity, which could inform targeted therapeutic strategies for ARDS and other pulmonary diseases.<\/jats:p>","DOI":"10.1002\/cph4.70025","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:03:47Z","timestamp":1752127427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leptin and Acute Lung Disorders"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-747X","authenticated-orcid":false,"given":"Alice","family":"Huertas","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, School of Medicine DYNAMIC Lab  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahar","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Vagelos Columbia University College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.413"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06348-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa112"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-312OC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.10.1059"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.032"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00092404"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8090"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-105X.1000144"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-318"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069297"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-020-00464-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.09.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03199-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0301OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81558-5"},{"key":"e_1_2_8_18_1","first-page":"2003","article-title":"Prevalence of Metabolic Syndrome Among Adults 20\u2009Years of Age and Over, by Sex, Age, Race and Ethnicity, and Body Mass Index: United States, 2003\u20102006","volume":"13","author":"Ervin R. 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