{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:34:00Z","timestamp":1789094040248,"version":"build-2803163510"},"reference-count":199,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018936","name":"Qingdao Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["QDBSH20230102096"],"award-info":[{"award-number":["QDBSH20230102096"]}],"id":[{"id":"10.13039\/100018936","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017630","name":"Humanities and Social Sciences Youth Foundation, Ministry of Education","doi-asserted-by":"publisher","award":["24YJC190022"],"award-info":[{"award-number":["24YJC190022"]}],"id":[{"id":"10.13039\/501100017630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The global aging population is driving age\u2010related diseases to become a significant public health challenge. Sarcopenia, an age\u2010related condition marked by muscle mass loss, reduced muscle strength, and\/or diminished physical function, contributes to a higher incidence of falls, fractures, hospitalizations, and mortality among affected individuals. Exercise is widely recognized as an affordable and sustainable approach to preventing and managing sarcopenia. This review explores the pathogenesis of sarcopenia, examines how various exercise modalities influence its underlying mechanisms, and elucidates the molecular pathways through which exercise mitigates the condition. By providing a thorough overview, this review aims to identify potential therapeutic targets for sarcopenia, ultimately supporting efforts to reduce the burden on global healthcare systems and address the challenges of an aging population.<\/jats:p>","DOI":"10.1002\/cph4.70030","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:43:52Z","timestamp":1753443832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mechanisms of Exercise in Improving Sarcopenia"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8085-6157","authenticated-orcid":false,"given":"Mengzhu","family":"Su","sequence":"first","affiliation":[{"name":"Cancer Institute, Qingdao Cancer Institute, The Affiliated Hospital of Qingdao University Qingdao University  Qingdao China"},{"name":"School of Physical Education Qingdao University  Qingdao 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