{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:32:44Z","timestamp":1792099964569,"version":"4.4.0"},"reference-count":151,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Placental dysfunction is implicated in the pathogenesis of multiple pregnancy complications. Mitochondria are the powerhouse of the cell and are critical for placental metabolism and function. Several pregnancy complications are associated with oxidative stress and mitochondrial alterations. Mitochondrial function is also essential for epigenetic modifications, which are pivotal in regulating gene expression during pregnancy. Extracellular vesicles (EVs) carry and transfer a variety of biological molecules, including intact mitochondria and mitochondrial components, and act as modifiers of epigenetics in recipient cells. Changes in the EV profile may serve as biomarkers for pregnancy complications. In the present review, we summarize the associations of mitochondrial dysfunction, epigenetic alterations, and changes in EVs that are associated with pregnancy complications. We also describe the link between mitochondria and epigenetics, mitochondria in EVs, and EVs in epigenetic modifications, which provide insight into the possible implications of crosstalk among mitochondria, epigenetics, and EVs in regulating placental function and adverse pregnancy outcomes.<\/jats:p>","DOI":"10.1002\/cph4.70040","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:54:54Z","timestamp":1755582894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deciphering the Molecular Dialogue: Mitochondria, Epigenetics, and Extracellular Vesicles in Placental Function and Pregnancy Complications"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-1794","authenticated-orcid":false,"given":"Yu\u2010Chin","family":"Lien","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Center for Women's Health and Reproductive Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-8904","authenticated-orcid":false,"given":"Rebecca A.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Center for Women's Health and Reproductive Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061445"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.3.839"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2008.08.013"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190698"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0123-0"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.671093"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86268-1"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.07.011"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.001"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.07.004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106488"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.01.002"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2017.09.002"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat044"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.39564"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316486"},{"key":"e_1_2_14_18_1","first-page":"45","article-title":"Placental Apoptosis in Preeclampsia, Intrauterine Growth Retardation, and HELLP Syndrome: An Immunohistochemical Study With Caspase\u20103 and Bcl\u20102","volume":"40","author":"Cali U.","year":"2013","journal-title":"Clinical and Experimental Obstetrics & Gynecology"},{"key":"e_1_2_14_19_1","first-page":"611","article-title":"Evaluation of Proteomic Biomarkers Associated With Circulating Microparticles as an Effective Means to Stratify the Risk of Spontaneous Preterm Birth","volume":"214","author":"Cantonwine D. 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