{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:07:14Z","timestamp":1761556034024,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary hypertension (PH) is a progressive condition characterized by muscularization of precapillary arteries, chronic inflammation, and a loss of the distal pulmonary circulation. These changes can be mimicked in rats by monocrotaline (MCT) administration. The impact of MCT\u2010induced pulmonary damage on ventilatory control is poorly understood. In this study, we investigated whether the severity of PH induced by MCT in rats is linked to ventilatory changes. We examined ventilatory variables in awake (plethysmographic) and anesthetized (tracheal) rats, stratified by disease severity (Fulton's index). Two subgroups were identified: mild (Fulton's index &lt;\u20090.49) and severe (Fulton's index &gt;\u20090.53) PH. Resting ventilation was significantly increased in severe but not mild PH rats compared to controls, in both awake and anesthetized states. However, the responses to a carotid chemoreflex were similar between all groups. The variability of ventilatory variables was elevated in both groups of PH rats compared to controls, with a more pronounced increase in animals severely affected. Disease severity was also associated with increased adrenal gland weight, reduced brain\u2010derived neurotrophic factor (BDNF) levels, and prolonged grooming, suggesting a heightened arousal state in severe PH rats. Interestingly, these alterations were reversed by inhibition of the dorsomedial hypothalamus area, a key structure in stress defense responses, and the blockade of the parabrachial complex, which projects onto the central ventral respiratory group. These findings suggest that PH\u2010induced changes, whether due to vascular remodeling and\/or right ventricular dysfunction, are associated with severity\u2010dependent ventilatory alterations, possibly mediated via stress\u2010related neural activation.<\/jats:p>","DOI":"10.1002\/cph4.70055","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:54:17Z","timestamp":1758725657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Ventilation in Rats With Established Severe Monocrotaline\u2010Induced Pulmonary Hypertension: The Role of the Dorsal Hypothalamus"],"prefix":"10.1002","volume":"15","author":[{"given":"Aliaume","family":"Le Pape","sequence":"first","affiliation":[{"name":"INSERM UMRS1158 Neurophysiologie Respiratoire exp\u00e9rimentale et Clinique, Sorbonne Universit\u00e9  Paris 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INSERM 1018, CESP (Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations) Facult\u00e9 de M\u00e9decine Paris\u2010Saclay, Universit\u00e9 Paris\u2010Saclay  Le Kremlin Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"INSERM UMRS1158 Neurophysiologie Respiratoire exp\u00e9rimentale et Clinique, Sorbonne Universit\u00e9  Paris France"},{"name":"Service Des Explorations Fonctionnelles de la Respiration, de L\u2018exercice et de la Dyspn\u00e9e du D\u00e9partement R3S AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4570-6384","authenticated-orcid":false,"given":"Caroline","family":"Sevoz\u2010Couche","sequence":"additional","affiliation":[{"name":"INSERM UMRS1158 Neurophysiologie Respiratoire exp\u00e9rimentale et 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