{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:53:18Z","timestamp":1777549998021,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL135158"],"award-info":[{"award-number":["R01HL135158"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL164398"],"award-info":[{"award-number":["R01HL164398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Previously, we showed that male mice subjected to Maternal Separation and Early Weaning (MSEW), a model of early life stress, exhibit heightened cardiovascular responses to hypertensive stimuli. This study aimed to determine whether MSEW increases blood pressure salt sensitivity. Male C57BL\/6J mouse pups were separated daily from their dams for 4\u20138\u2009h from postnatal Day 2\u201316. MSEW mice were weaned the following day, while control litters were normally reared and weaned at postnatal Day 21, after which all mice were placed on a low\u2010fat, normal salt diet (LFNS, 10% kcal from fat, 0.4% NaCl) for 20\u2009weeks. Subsequently, mice were randomized to either LFNS or a low\u2010fat, high\u2010salt diet (LFHS, 10% kcal from fat, 4.0% NaCl) for an additional 6\u2009weeks. MSEW induced sympathetic overactivity in mice on the LFNS diet, evidenced by increased urinary NE excretion, reduced low\u2010frequency heart rate variability, and downregulation of cardiac adrenergic receptors compared to control mice. Despite diminished cardiac parasympathetic activation compared to controls, MSEW mice showed enhanced water and electrolyte excretion in response to increased dietary sodium content during daytime hours. Taken together, MSEW increases the basal sympathetic tone and reduces the overall adaptability and responsiveness of the cardiovascular system to increases in dietary sodium content. This impaired autonomic regulation of blood pressure and heart rate variability may favor the development of cardiovascular dysfunction in settings of renal disease where the kidneys lack the capacity to compensate for the excess of sodium intake.<\/jats:p>","DOI":"10.1002\/cph4.70059","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T03:54:19Z","timestamp":1760068459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lean Mice Exposed to Early Life Stress Exhibit Increased Basal Sympathetic Tone and Blunted Parasympathetic Activation in Response to High Salt Diet"],"prefix":"10.1002","volume":"15","author":[{"given":"Sundus","family":"Ghuneim","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Dalmasso","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"B. Turner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u2010Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming C.","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Kentucky  Lexington Kentucky USA"},{"name":"SAHA Cardiovascular Research Center University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Stauss","sequence":"additional","affiliation":[{"name":"Burrell College of Osteopathic Medicine  Las Cruces New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Analia 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20262"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010019\u201000126\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.17959"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00488.2006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.5.558"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.14519"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.029511"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17298"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S379874"},{"key":"e_1_2_9_12_1","unstructured":"DietaryGuidelinesgov.2020.\u201cDietary 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